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Hyperosmotic stress memory in Arabidopsis is mediated by distinct epigenetically labile sites in the genome and is restricted in the male germline by DNA glycosylase activity

Inducible epigenetic changes in eukaryotes are believed to enable rapid adaptation to environmental fluctuations. We have found distinct regions of the Arabidopsis genome that are susceptible to DNA (de)methylation in response to hyperosmotic stress. The stress-induced epigenetic changes are associa...

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Autores principales: Wibowo, Anjar, Becker, Claude, Marconi, Gianpiero, Durr, Julius, Price, Jonathan, Hagmann, Jorg, Papareddy, Ranjith, Putra, Hadi, Kageyama, Jorge, Becker, Jorg, Weigel, Detlef, Gutierrez-Marcos, Jose
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887212/
https://www.ncbi.nlm.nih.gov/pubmed/27242129
http://dx.doi.org/10.7554/eLife.13546
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author Wibowo, Anjar
Becker, Claude
Marconi, Gianpiero
Durr, Julius
Price, Jonathan
Hagmann, Jorg
Papareddy, Ranjith
Putra, Hadi
Kageyama, Jorge
Becker, Jorg
Weigel, Detlef
Gutierrez-Marcos, Jose
author_facet Wibowo, Anjar
Becker, Claude
Marconi, Gianpiero
Durr, Julius
Price, Jonathan
Hagmann, Jorg
Papareddy, Ranjith
Putra, Hadi
Kageyama, Jorge
Becker, Jorg
Weigel, Detlef
Gutierrez-Marcos, Jose
author_sort Wibowo, Anjar
collection PubMed
description Inducible epigenetic changes in eukaryotes are believed to enable rapid adaptation to environmental fluctuations. We have found distinct regions of the Arabidopsis genome that are susceptible to DNA (de)methylation in response to hyperosmotic stress. The stress-induced epigenetic changes are associated with conditionally heritable adaptive phenotypic stress responses. However, these stress responses are primarily transmitted to the next generation through the female lineage due to widespread DNA glycosylase activity in the male germline, and extensively reset in the absence of stress. Using the CNI1/ATL31 locus as an example, we demonstrate that epigenetically targeted sequences function as distantly-acting control elements of antisense long non-coding RNAs, which in turn regulate targeted gene expression in response to stress. Collectively, our findings reveal that plants use a highly dynamic maternal ‘short-term stress memory’ with which to respond to adverse external conditions. This transient memory relies on the DNA methylation machinery and associated transcriptional changes to extend the phenotypic plasticity accessible to the immediate offspring.
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spelling pubmed-48872122016-06-02 Hyperosmotic stress memory in Arabidopsis is mediated by distinct epigenetically labile sites in the genome and is restricted in the male germline by DNA glycosylase activity Wibowo, Anjar Becker, Claude Marconi, Gianpiero Durr, Julius Price, Jonathan Hagmann, Jorg Papareddy, Ranjith Putra, Hadi Kageyama, Jorge Becker, Jorg Weigel, Detlef Gutierrez-Marcos, Jose eLife Computational and Systems Biology Inducible epigenetic changes in eukaryotes are believed to enable rapid adaptation to environmental fluctuations. We have found distinct regions of the Arabidopsis genome that are susceptible to DNA (de)methylation in response to hyperosmotic stress. The stress-induced epigenetic changes are associated with conditionally heritable adaptive phenotypic stress responses. However, these stress responses are primarily transmitted to the next generation through the female lineage due to widespread DNA glycosylase activity in the male germline, and extensively reset in the absence of stress. Using the CNI1/ATL31 locus as an example, we demonstrate that epigenetically targeted sequences function as distantly-acting control elements of antisense long non-coding RNAs, which in turn regulate targeted gene expression in response to stress. Collectively, our findings reveal that plants use a highly dynamic maternal ‘short-term stress memory’ with which to respond to adverse external conditions. This transient memory relies on the DNA methylation machinery and associated transcriptional changes to extend the phenotypic plasticity accessible to the immediate offspring. eLife Sciences Publications, Ltd 2016-05-31 /pmc/articles/PMC4887212/ /pubmed/27242129 http://dx.doi.org/10.7554/eLife.13546 Text en © 2016, Wibowo et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Computational and Systems Biology
Wibowo, Anjar
Becker, Claude
Marconi, Gianpiero
Durr, Julius
Price, Jonathan
Hagmann, Jorg
Papareddy, Ranjith
Putra, Hadi
Kageyama, Jorge
Becker, Jorg
Weigel, Detlef
Gutierrez-Marcos, Jose
Hyperosmotic stress memory in Arabidopsis is mediated by distinct epigenetically labile sites in the genome and is restricted in the male germline by DNA glycosylase activity
title Hyperosmotic stress memory in Arabidopsis is mediated by distinct epigenetically labile sites in the genome and is restricted in the male germline by DNA glycosylase activity
title_full Hyperosmotic stress memory in Arabidopsis is mediated by distinct epigenetically labile sites in the genome and is restricted in the male germline by DNA glycosylase activity
title_fullStr Hyperosmotic stress memory in Arabidopsis is mediated by distinct epigenetically labile sites in the genome and is restricted in the male germline by DNA glycosylase activity
title_full_unstemmed Hyperosmotic stress memory in Arabidopsis is mediated by distinct epigenetically labile sites in the genome and is restricted in the male germline by DNA glycosylase activity
title_short Hyperosmotic stress memory in Arabidopsis is mediated by distinct epigenetically labile sites in the genome and is restricted in the male germline by DNA glycosylase activity
title_sort hyperosmotic stress memory in arabidopsis is mediated by distinct epigenetically labile sites in the genome and is restricted in the male germline by dna glycosylase activity
topic Computational and Systems Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887212/
https://www.ncbi.nlm.nih.gov/pubmed/27242129
http://dx.doi.org/10.7554/eLife.13546
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