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Hyperosmotic stress memory in Arabidopsis is mediated by distinct epigenetically labile sites in the genome and is restricted in the male germline by DNA glycosylase activity
Inducible epigenetic changes in eukaryotes are believed to enable rapid adaptation to environmental fluctuations. We have found distinct regions of the Arabidopsis genome that are susceptible to DNA (de)methylation in response to hyperosmotic stress. The stress-induced epigenetic changes are associa...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887212/ https://www.ncbi.nlm.nih.gov/pubmed/27242129 http://dx.doi.org/10.7554/eLife.13546 |
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author | Wibowo, Anjar Becker, Claude Marconi, Gianpiero Durr, Julius Price, Jonathan Hagmann, Jorg Papareddy, Ranjith Putra, Hadi Kageyama, Jorge Becker, Jorg Weigel, Detlef Gutierrez-Marcos, Jose |
author_facet | Wibowo, Anjar Becker, Claude Marconi, Gianpiero Durr, Julius Price, Jonathan Hagmann, Jorg Papareddy, Ranjith Putra, Hadi Kageyama, Jorge Becker, Jorg Weigel, Detlef Gutierrez-Marcos, Jose |
author_sort | Wibowo, Anjar |
collection | PubMed |
description | Inducible epigenetic changes in eukaryotes are believed to enable rapid adaptation to environmental fluctuations. We have found distinct regions of the Arabidopsis genome that are susceptible to DNA (de)methylation in response to hyperosmotic stress. The stress-induced epigenetic changes are associated with conditionally heritable adaptive phenotypic stress responses. However, these stress responses are primarily transmitted to the next generation through the female lineage due to widespread DNA glycosylase activity in the male germline, and extensively reset in the absence of stress. Using the CNI1/ATL31 locus as an example, we demonstrate that epigenetically targeted sequences function as distantly-acting control elements of antisense long non-coding RNAs, which in turn regulate targeted gene expression in response to stress. Collectively, our findings reveal that plants use a highly dynamic maternal ‘short-term stress memory’ with which to respond to adverse external conditions. This transient memory relies on the DNA methylation machinery and associated transcriptional changes to extend the phenotypic plasticity accessible to the immediate offspring. |
format | Online Article Text |
id | pubmed-4887212 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-48872122016-06-02 Hyperosmotic stress memory in Arabidopsis is mediated by distinct epigenetically labile sites in the genome and is restricted in the male germline by DNA glycosylase activity Wibowo, Anjar Becker, Claude Marconi, Gianpiero Durr, Julius Price, Jonathan Hagmann, Jorg Papareddy, Ranjith Putra, Hadi Kageyama, Jorge Becker, Jorg Weigel, Detlef Gutierrez-Marcos, Jose eLife Computational and Systems Biology Inducible epigenetic changes in eukaryotes are believed to enable rapid adaptation to environmental fluctuations. We have found distinct regions of the Arabidopsis genome that are susceptible to DNA (de)methylation in response to hyperosmotic stress. The stress-induced epigenetic changes are associated with conditionally heritable adaptive phenotypic stress responses. However, these stress responses are primarily transmitted to the next generation through the female lineage due to widespread DNA glycosylase activity in the male germline, and extensively reset in the absence of stress. Using the CNI1/ATL31 locus as an example, we demonstrate that epigenetically targeted sequences function as distantly-acting control elements of antisense long non-coding RNAs, which in turn regulate targeted gene expression in response to stress. Collectively, our findings reveal that plants use a highly dynamic maternal ‘short-term stress memory’ with which to respond to adverse external conditions. This transient memory relies on the DNA methylation machinery and associated transcriptional changes to extend the phenotypic plasticity accessible to the immediate offspring. eLife Sciences Publications, Ltd 2016-05-31 /pmc/articles/PMC4887212/ /pubmed/27242129 http://dx.doi.org/10.7554/eLife.13546 Text en © 2016, Wibowo et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Computational and Systems Biology Wibowo, Anjar Becker, Claude Marconi, Gianpiero Durr, Julius Price, Jonathan Hagmann, Jorg Papareddy, Ranjith Putra, Hadi Kageyama, Jorge Becker, Jorg Weigel, Detlef Gutierrez-Marcos, Jose Hyperosmotic stress memory in Arabidopsis is mediated by distinct epigenetically labile sites in the genome and is restricted in the male germline by DNA glycosylase activity |
title | Hyperosmotic stress memory in Arabidopsis is mediated by distinct epigenetically labile sites in the genome and is restricted in the male germline by DNA glycosylase activity |
title_full | Hyperosmotic stress memory in Arabidopsis is mediated by distinct epigenetically labile sites in the genome and is restricted in the male germline by DNA glycosylase activity |
title_fullStr | Hyperosmotic stress memory in Arabidopsis is mediated by distinct epigenetically labile sites in the genome and is restricted in the male germline by DNA glycosylase activity |
title_full_unstemmed | Hyperosmotic stress memory in Arabidopsis is mediated by distinct epigenetically labile sites in the genome and is restricted in the male germline by DNA glycosylase activity |
title_short | Hyperosmotic stress memory in Arabidopsis is mediated by distinct epigenetically labile sites in the genome and is restricted in the male germline by DNA glycosylase activity |
title_sort | hyperosmotic stress memory in arabidopsis is mediated by distinct epigenetically labile sites in the genome and is restricted in the male germline by dna glycosylase activity |
topic | Computational and Systems Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887212/ https://www.ncbi.nlm.nih.gov/pubmed/27242129 http://dx.doi.org/10.7554/eLife.13546 |
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