Deacetylation of TFEB promotes fibrillar Aβ degradation by upregulating lysosomal biogenesis in microglia

Microglia play a pivotal role in clearance of Aβ by degrading them in lysosomes, countering amyloid plaque pathogenesis in Alzheimer’s disease (AD). Recent evidence suggests that lysosomal dysfunction leads to insufficient elimination of toxic protein aggregates. We tested whether enhancing lysosoma...

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Detalles Bibliográficos
Autores principales: Bao, Jintao, Zheng, Liangjun, Zhang, Qi, Li, Xinya, Zhang, Xuefei, Li, Zeyang, Bai, Xue, Zhang, Zhong, Huo, Wei, Zhao, Xuyang, Shang, Shujiang, Wang, Qingsong, Zhang, Chen, Ji, Jianguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Higher Education Press 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887328/
https://www.ncbi.nlm.nih.gov/pubmed/27209302
http://dx.doi.org/10.1007/s13238-016-0269-2

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