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A Possible Common Neurophysiologic Basis for MDD, Bipolar Disorder, and Schizophrenia: Lessons from Electrophysiology

There is ample electrophysiological evidence of attention dysfunction in the EEG/ERP signal of major depressive disorder (MDD), bipolar disorder, and schizophrenia. The reduced attention-related ERP waves show much similarity between MDD, bipolar disorder, and schizophrenia, raising the question whe...

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Detalles Bibliográficos
Autor principal: Shahaf, Goded
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887471/
https://www.ncbi.nlm.nih.gov/pubmed/27313546
http://dx.doi.org/10.3389/fpsyt.2016.00094
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author Shahaf, Goded
author_facet Shahaf, Goded
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description There is ample electrophysiological evidence of attention dysfunction in the EEG/ERP signal of major depressive disorder (MDD), bipolar disorder, and schizophrenia. The reduced attention-related ERP waves show much similarity between MDD, bipolar disorder, and schizophrenia, raising the question whether there are similarities in the neurophysiologic process that underlies attention dysfunction in these pathologies. The present work suggests that there is such a unified underlying neurophysiologic process, which results in reduced attention in the three pathologies. Naturally, as these pathologies involve different clinical manifestations, we expect differences in their underlying neurophysiology. These differences and their subtle manifestation in the ERP marker for attention are also discussed. MDD, bipolar disorder, and schizophrenia are just three of multiple neuropsychiatric disorders, which involve changes in the EEG/ERP manifestations of attention. Further work should expand the basic model presented here to offer comprehensive modeling of these multiple disorders and to emphasize similarities and dissimilarities of the underlying neurophysiologic processes.
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spelling pubmed-48874712016-06-16 A Possible Common Neurophysiologic Basis for MDD, Bipolar Disorder, and Schizophrenia: Lessons from Electrophysiology Shahaf, Goded Front Psychiatry Psychiatry There is ample electrophysiological evidence of attention dysfunction in the EEG/ERP signal of major depressive disorder (MDD), bipolar disorder, and schizophrenia. The reduced attention-related ERP waves show much similarity between MDD, bipolar disorder, and schizophrenia, raising the question whether there are similarities in the neurophysiologic process that underlies attention dysfunction in these pathologies. The present work suggests that there is such a unified underlying neurophysiologic process, which results in reduced attention in the three pathologies. Naturally, as these pathologies involve different clinical manifestations, we expect differences in their underlying neurophysiology. These differences and their subtle manifestation in the ERP marker for attention are also discussed. MDD, bipolar disorder, and schizophrenia are just three of multiple neuropsychiatric disorders, which involve changes in the EEG/ERP manifestations of attention. Further work should expand the basic model presented here to offer comprehensive modeling of these multiple disorders and to emphasize similarities and dissimilarities of the underlying neurophysiologic processes. Frontiers Media S.A. 2016-06-01 /pmc/articles/PMC4887471/ /pubmed/27313546 http://dx.doi.org/10.3389/fpsyt.2016.00094 Text en Copyright © 2016 Shahaf. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Shahaf, Goded
A Possible Common Neurophysiologic Basis for MDD, Bipolar Disorder, and Schizophrenia: Lessons from Electrophysiology
title A Possible Common Neurophysiologic Basis for MDD, Bipolar Disorder, and Schizophrenia: Lessons from Electrophysiology
title_full A Possible Common Neurophysiologic Basis for MDD, Bipolar Disorder, and Schizophrenia: Lessons from Electrophysiology
title_fullStr A Possible Common Neurophysiologic Basis for MDD, Bipolar Disorder, and Schizophrenia: Lessons from Electrophysiology
title_full_unstemmed A Possible Common Neurophysiologic Basis for MDD, Bipolar Disorder, and Schizophrenia: Lessons from Electrophysiology
title_short A Possible Common Neurophysiologic Basis for MDD, Bipolar Disorder, and Schizophrenia: Lessons from Electrophysiology
title_sort possible common neurophysiologic basis for mdd, bipolar disorder, and schizophrenia: lessons from electrophysiology
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887471/
https://www.ncbi.nlm.nih.gov/pubmed/27313546
http://dx.doi.org/10.3389/fpsyt.2016.00094
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