Interleukin (IL)-4 -590C>T polymorphism is not associated with the susceptibility of gastric cancer: An updated meta-analysis

Gastric cancer (GC) is a common cancer affecting patients around the world. The pathogenesis of gastric cancer has not been understood completely. Genetic mutations and the inflammation induced by Helicobacter pylori (HP) seem to play important roles. The cytokine Interleukin-4 (IL-4) has effects in...

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Detalles Bibliográficos
Autores principales: Wang, Tie, Tian, Lining, Gao, Meizhuo, Song, Hongjiang, Wei, Yuzhe, Xue, Yingwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887560/
https://www.ncbi.nlm.nih.gov/pubmed/27284401
http://dx.doi.org/10.1016/j.amsu.2016.05.011
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author Wang, Tie
Tian, Lining
Gao, Meizhuo
Song, Hongjiang
Wei, Yuzhe
Xue, Yingwei
author_facet Wang, Tie
Tian, Lining
Gao, Meizhuo
Song, Hongjiang
Wei, Yuzhe
Xue, Yingwei
author_sort Wang, Tie
collection PubMed
description Gastric cancer (GC) is a common cancer affecting patients around the world. The pathogenesis of gastric cancer has not been understood completely. Genetic mutations and the inflammation induced by Helicobacter pylori (HP) seem to play important roles. The cytokine Interleukin-4 (IL-4) has effects in inflammation, allergies and cancer including GC. The association of IL-4 -590 C>T polymorphism and gastric cancer has been studied in different populations with inconsistent results. Here, we report this meta-analysis showing that the polymorphism of IL-4 -590C>T might not be associated with the GC susceptibility in both Asian and Caucasian populations.
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spelling pubmed-48875602016-06-09 Interleukin (IL)-4 -590C>T polymorphism is not associated with the susceptibility of gastric cancer: An updated meta-analysis Wang, Tie Tian, Lining Gao, Meizhuo Song, Hongjiang Wei, Yuzhe Xue, Yingwei Ann Med Surg (Lond) Review Gastric cancer (GC) is a common cancer affecting patients around the world. The pathogenesis of gastric cancer has not been understood completely. Genetic mutations and the inflammation induced by Helicobacter pylori (HP) seem to play important roles. The cytokine Interleukin-4 (IL-4) has effects in inflammation, allergies and cancer including GC. The association of IL-4 -590 C>T polymorphism and gastric cancer has been studied in different populations with inconsistent results. Here, we report this meta-analysis showing that the polymorphism of IL-4 -590C>T might not be associated with the GC susceptibility in both Asian and Caucasian populations. Elsevier 2016-05-18 /pmc/articles/PMC4887560/ /pubmed/27284401 http://dx.doi.org/10.1016/j.amsu.2016.05.011 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Wang, Tie
Tian, Lining
Gao, Meizhuo
Song, Hongjiang
Wei, Yuzhe
Xue, Yingwei
Interleukin (IL)-4 -590C>T polymorphism is not associated with the susceptibility of gastric cancer: An updated meta-analysis
title Interleukin (IL)-4 -590C>T polymorphism is not associated with the susceptibility of gastric cancer: An updated meta-analysis
title_full Interleukin (IL)-4 -590C>T polymorphism is not associated with the susceptibility of gastric cancer: An updated meta-analysis
title_fullStr Interleukin (IL)-4 -590C>T polymorphism is not associated with the susceptibility of gastric cancer: An updated meta-analysis
title_full_unstemmed Interleukin (IL)-4 -590C>T polymorphism is not associated with the susceptibility of gastric cancer: An updated meta-analysis
title_short Interleukin (IL)-4 -590C>T polymorphism is not associated with the susceptibility of gastric cancer: An updated meta-analysis
title_sort interleukin (il)-4 -590c>t polymorphism is not associated with the susceptibility of gastric cancer: an updated meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887560/
https://www.ncbi.nlm.nih.gov/pubmed/27284401
http://dx.doi.org/10.1016/j.amsu.2016.05.011
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