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Sialoblastoma of the cheek: A case report and review of the literature

Sialoblastoma is a rare salivary gland tumor that recapitulates the primitive salivary gland anlage. The authors herein report a case of sialoblastoma of a minor salivary gland, clinically presenting with progressive enlargement of a mass in the cheek of a 1-year-old female infant. Histopathological...

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Autores principales: SITTHICHAIYAKUL, PEERAYUT, SOMRAN, JULINTORN, OILMUNGMOOL, NONGLUK, WORASAKWUTTIPONG, SARAN, LARBCHAROENSUB, NOPPADOL
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887838/
https://www.ncbi.nlm.nih.gov/pubmed/27284424
http://dx.doi.org/10.3892/mco.2016.840
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author SITTHICHAIYAKUL, PEERAYUT
SOMRAN, JULINTORN
OILMUNGMOOL, NONGLUK
WORASAKWUTTIPONG, SARAN
LARBCHAROENSUB, NOPPADOL
author_facet SITTHICHAIYAKUL, PEERAYUT
SOMRAN, JULINTORN
OILMUNGMOOL, NONGLUK
WORASAKWUTTIPONG, SARAN
LARBCHAROENSUB, NOPPADOL
author_sort SITTHICHAIYAKUL, PEERAYUT
collection PubMed
description Sialoblastoma is a rare salivary gland tumor that recapitulates the primitive salivary gland anlage. The authors herein report a case of sialoblastoma of a minor salivary gland, clinically presenting with progressive enlargement of a mass in the cheek of a 1-year-old female infant. Histopathologically, the mass consisted of tight clusters of basaloid cells and partially formed ductal and pseudo-ductal spaces separated by thin fibrous bands. Immunohistchemical studies demonstrated the presence of cytokeratin AE1/AE3, p63, CD99, α-fetoprotein (AFP) and Hep Par-1 expression in a considerable number of tumor cells. The clinical and pathological characteristics are presented and relevant literature is reviewed. Early complete surgical excision is recommended for the treatment of sialoblastoma. Radiation may be considered in cases with incomplete resection of the tumor. Chemotherapy may play a vital role in extensive, metastatic, or relapsed cases, or in cases with inadequate excision. The follow-up treatment should be frequent and prolonged. To the best of our knowledge, this is the first reported case of sialoblastoma of the cheek with immunoreactivity for AFP and Hep Par-1, which may be associated with the embryonic origin of the tumor. AFP may be a useful marker of tumor response in patient with sialoblastoma.
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spelling pubmed-48878382016-06-09 Sialoblastoma of the cheek: A case report and review of the literature SITTHICHAIYAKUL, PEERAYUT SOMRAN, JULINTORN OILMUNGMOOL, NONGLUK WORASAKWUTTIPONG, SARAN LARBCHAROENSUB, NOPPADOL Mol Clin Oncol Articles Sialoblastoma is a rare salivary gland tumor that recapitulates the primitive salivary gland anlage. The authors herein report a case of sialoblastoma of a minor salivary gland, clinically presenting with progressive enlargement of a mass in the cheek of a 1-year-old female infant. Histopathologically, the mass consisted of tight clusters of basaloid cells and partially formed ductal and pseudo-ductal spaces separated by thin fibrous bands. Immunohistchemical studies demonstrated the presence of cytokeratin AE1/AE3, p63, CD99, α-fetoprotein (AFP) and Hep Par-1 expression in a considerable number of tumor cells. The clinical and pathological characteristics are presented and relevant literature is reviewed. Early complete surgical excision is recommended for the treatment of sialoblastoma. Radiation may be considered in cases with incomplete resection of the tumor. Chemotherapy may play a vital role in extensive, metastatic, or relapsed cases, or in cases with inadequate excision. The follow-up treatment should be frequent and prolonged. To the best of our knowledge, this is the first reported case of sialoblastoma of the cheek with immunoreactivity for AFP and Hep Par-1, which may be associated with the embryonic origin of the tumor. AFP may be a useful marker of tumor response in patient with sialoblastoma. D.A. Spandidos 2016-06 2016-03-30 /pmc/articles/PMC4887838/ /pubmed/27284424 http://dx.doi.org/10.3892/mco.2016.840 Text en Copyright: © Sitthichaiyakul et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
SITTHICHAIYAKUL, PEERAYUT
SOMRAN, JULINTORN
OILMUNGMOOL, NONGLUK
WORASAKWUTTIPONG, SARAN
LARBCHAROENSUB, NOPPADOL
Sialoblastoma of the cheek: A case report and review of the literature
title Sialoblastoma of the cheek: A case report and review of the literature
title_full Sialoblastoma of the cheek: A case report and review of the literature
title_fullStr Sialoblastoma of the cheek: A case report and review of the literature
title_full_unstemmed Sialoblastoma of the cheek: A case report and review of the literature
title_short Sialoblastoma of the cheek: A case report and review of the literature
title_sort sialoblastoma of the cheek: a case report and review of the literature
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887838/
https://www.ncbi.nlm.nih.gov/pubmed/27284424
http://dx.doi.org/10.3892/mco.2016.840
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