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Prognostic significance of Dicer expression in hepatocellular carcinoma

Dicer is a RNaseIII endonuclease of the microRNA processing pathway, which is implicated in carcinogenesis of various types of human cancer. The present study assessed the expression level of Dicer in hepatocellular carcinoma (HCC) tissue to evaluate its association with HCC tumorigenesis. A low exp...

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Autores principales: ZHANG, LI, WANG, CUIJU, LIU, SHUFENG, ZHAO, YUFEI, LIU, CHAO, GUO, ZHANJUN
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888077/
https://www.ncbi.nlm.nih.gov/pubmed/27313724
http://dx.doi.org/10.3892/ol.2016.4547
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author ZHANG, LI
WANG, CUIJU
LIU, SHUFENG
ZHAO, YUFEI
LIU, CHAO
GUO, ZHANJUN
author_facet ZHANG, LI
WANG, CUIJU
LIU, SHUFENG
ZHAO, YUFEI
LIU, CHAO
GUO, ZHANJUN
author_sort ZHANG, LI
collection PubMed
description Dicer is a RNaseIII endonuclease of the microRNA processing pathway, which is implicated in carcinogenesis of various types of human cancer. The present study assessed the expression level of Dicer in hepatocellular carcinoma (HCC) tissue to evaluate its association with HCC tumorigenesis. A low expression of Dicer was significantly associated with a shorter postoperative survival time of patients with HCC, which was assessed using the log-rank test with Kaplan-Meier survival analysis. Multivariate analysis identified that Dicer expression was an independent predictor for HCC outcome (relative risk, 0.660; 95% confidence interval, 0.506–0.861; P=0.002). A functional assay demonstrated that Dicer overexpression inhibited the proliferation and promoted the apoptosis of HCC cells. In addition, a Transwell assay revealed that Dicer markedly inhibited the migration and invasion of HCC cells. The present findings indicate that Dicer expression modified the outcomes of HCC patients by inhibiting proliferation, promoting apoptosis and inhibiting metastasis of HCC cells.
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spelling pubmed-48880772016-06-16 Prognostic significance of Dicer expression in hepatocellular carcinoma ZHANG, LI WANG, CUIJU LIU, SHUFENG ZHAO, YUFEI LIU, CHAO GUO, ZHANJUN Oncol Lett Articles Dicer is a RNaseIII endonuclease of the microRNA processing pathway, which is implicated in carcinogenesis of various types of human cancer. The present study assessed the expression level of Dicer in hepatocellular carcinoma (HCC) tissue to evaluate its association with HCC tumorigenesis. A low expression of Dicer was significantly associated with a shorter postoperative survival time of patients with HCC, which was assessed using the log-rank test with Kaplan-Meier survival analysis. Multivariate analysis identified that Dicer expression was an independent predictor for HCC outcome (relative risk, 0.660; 95% confidence interval, 0.506–0.861; P=0.002). A functional assay demonstrated that Dicer overexpression inhibited the proliferation and promoted the apoptosis of HCC cells. In addition, a Transwell assay revealed that Dicer markedly inhibited the migration and invasion of HCC cells. The present findings indicate that Dicer expression modified the outcomes of HCC patients by inhibiting proliferation, promoting apoptosis and inhibiting metastasis of HCC cells. D.A. Spandidos 2016-06 2016-05-09 /pmc/articles/PMC4888077/ /pubmed/27313724 http://dx.doi.org/10.3892/ol.2016.4547 Text en Copyright: © Zhang et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
ZHANG, LI
WANG, CUIJU
LIU, SHUFENG
ZHAO, YUFEI
LIU, CHAO
GUO, ZHANJUN
Prognostic significance of Dicer expression in hepatocellular carcinoma
title Prognostic significance of Dicer expression in hepatocellular carcinoma
title_full Prognostic significance of Dicer expression in hepatocellular carcinoma
title_fullStr Prognostic significance of Dicer expression in hepatocellular carcinoma
title_full_unstemmed Prognostic significance of Dicer expression in hepatocellular carcinoma
title_short Prognostic significance of Dicer expression in hepatocellular carcinoma
title_sort prognostic significance of dicer expression in hepatocellular carcinoma
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888077/
https://www.ncbi.nlm.nih.gov/pubmed/27313724
http://dx.doi.org/10.3892/ol.2016.4547
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