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Association of the −243A>G, +61450C>A Polymorphisms of the Glutamate Decarboxylase 2 (GAD2) Gene with Obesity and Insulin Level in North Indian Population

BACKGROUND: Obesity associated with type 2 diabetes, and hypertension increased mortality and morbidity. Glutamate decarboxylase 2 (GAD2) gene is associated with obesity and it regulate food intake and insulin level. We investigated the association of GAD-2gene −243A>G (rs2236418) and +61450C>...

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Autores principales: PRAKASH, Jai, MITTAL, Balraj, AWASTHI, Shally, SRIVASTAVA, Neena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888173/
https://www.ncbi.nlm.nih.gov/pubmed/27252915
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author PRAKASH, Jai
MITTAL, Balraj
AWASTHI, Shally
SRIVASTAVA, Neena
author_facet PRAKASH, Jai
MITTAL, Balraj
AWASTHI, Shally
SRIVASTAVA, Neena
author_sort PRAKASH, Jai
collection PubMed
description BACKGROUND: Obesity associated with type 2 diabetes, and hypertension increased mortality and morbidity. Glutamate decarboxylase 2 (GAD2) gene is associated with obesity and it regulate food intake and insulin level. We investigated the association of GAD-2gene −243A>G (rs2236418) and +61450C>A (rs992990) polymorphisms with obesity and related phenotypes. METHODS: Insulin, glucose and lipid levels were estimated using standard protocols. All subjects were genotyped (PCR-RFLP) method. RESULTS: The −243A>G polymorphism of the GAD-2 gene was significantly associated with higher risk of obesity (P<0.05). CONCLUSION: GAD-2 gene polymorphisms influence obesity and related phenotype in complex manner, probably by regulating the food intake, insulin and body weight.
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spelling pubmed-48881732016-06-01 Association of the −243A>G, +61450C>A Polymorphisms of the Glutamate Decarboxylase 2 (GAD2) Gene with Obesity and Insulin Level in North Indian Population PRAKASH, Jai MITTAL, Balraj AWASTHI, Shally SRIVASTAVA, Neena Iran J Public Health Original Article BACKGROUND: Obesity associated with type 2 diabetes, and hypertension increased mortality and morbidity. Glutamate decarboxylase 2 (GAD2) gene is associated with obesity and it regulate food intake and insulin level. We investigated the association of GAD-2gene −243A>G (rs2236418) and +61450C>A (rs992990) polymorphisms with obesity and related phenotypes. METHODS: Insulin, glucose and lipid levels were estimated using standard protocols. All subjects were genotyped (PCR-RFLP) method. RESULTS: The −243A>G polymorphism of the GAD-2 gene was significantly associated with higher risk of obesity (P<0.05). CONCLUSION: GAD-2 gene polymorphisms influence obesity and related phenotype in complex manner, probably by regulating the food intake, insulin and body weight. Tehran University of Medical Sciences 2016-04 /pmc/articles/PMC4888173/ /pubmed/27252915 Text en Copyright© Iranian Public Health Association & Tehran University of Medical Sciences This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Original Article
PRAKASH, Jai
MITTAL, Balraj
AWASTHI, Shally
SRIVASTAVA, Neena
Association of the −243A>G, +61450C>A Polymorphisms of the Glutamate Decarboxylase 2 (GAD2) Gene with Obesity and Insulin Level in North Indian Population
title Association of the −243A>G, +61450C>A Polymorphisms of the Glutamate Decarboxylase 2 (GAD2) Gene with Obesity and Insulin Level in North Indian Population
title_full Association of the −243A>G, +61450C>A Polymorphisms of the Glutamate Decarboxylase 2 (GAD2) Gene with Obesity and Insulin Level in North Indian Population
title_fullStr Association of the −243A>G, +61450C>A Polymorphisms of the Glutamate Decarboxylase 2 (GAD2) Gene with Obesity and Insulin Level in North Indian Population
title_full_unstemmed Association of the −243A>G, +61450C>A Polymorphisms of the Glutamate Decarboxylase 2 (GAD2) Gene with Obesity and Insulin Level in North Indian Population
title_short Association of the −243A>G, +61450C>A Polymorphisms of the Glutamate Decarboxylase 2 (GAD2) Gene with Obesity and Insulin Level in North Indian Population
title_sort association of the −243a>g, +61450c>a polymorphisms of the glutamate decarboxylase 2 (gad2) gene with obesity and insulin level in north indian population
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888173/
https://www.ncbi.nlm.nih.gov/pubmed/27252915
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