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miRISC and the CCR4–NOT complex silence mRNA targets independently of 43S ribosomal scanning

miRNAs associate with Argonaute (AGO) proteins to silence the expression of mRNA targets by inhibiting translation and promoting deadenylation, decapping, and mRNA degradation. A current model for silencing suggests that AGOs mediate these effects through the sequential recruitment of GW182 proteins...

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Detalles Bibliográficos
Autores principales:	Kuzuoğlu‐Öztürk, Duygu, Bhandari, Dipankar, Huntzinger, Eric, Fauser, Maria, Helms, Sigrun, Izaurralde, Elisa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888236/ https://www.ncbi.nlm.nih.gov/pubmed/27009120 http://dx.doi.org/10.15252/embj.201592901

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