L-Arginine supplementation inhibits the growth of breast cancer by enhancing innate and adaptive immune responses mediated by suppression of MDSCs in vivo

BACKGROUND: L-Arg is involved in many biological activities, including the activation of T cells. In breast cancer patients, L-Arg is depleted by nitric oxide synthase 2 (NOS2) and arginase 1 (ARG-1) produced by myeloid-derived suppressor cells (MDSCs). Our aim was to test whether L-Arg supplementat...

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Detalles Bibliográficos
Autores principales: Cao, Yu, Feng, Yonghui, Zhang, Yanjun, Zhu, Xiaotong, Jin, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888479/
https://www.ncbi.nlm.nih.gov/pubmed/27246354
http://dx.doi.org/10.1186/s12885-016-2376-0

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