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Role of SGK1 for fatty acid uptake, cell survival and radioresistance of NCI-H460 lung cancer cells exposed to acute or chronic cycling severe hypoxia

BACKGROUND: Unsaturated fatty acids (FA) are required for cancer cell growth. In normoxia cells can generate unsaturated FA from saturated stearic and palmitic acid by desaturation. However, since the desaturation step is oxygen-dependent hypoxic cancer cells display an increased dependence on the u...

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Detalles Bibliográficos
Autores principales:	Matschke, Johann, Wiebeck, Elisa, Hurst, Sebastian, Rudner, Justine, Jendrossek, Verena
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888512/ https://www.ncbi.nlm.nih.gov/pubmed/27251632 http://dx.doi.org/10.1186/s13014-016-0647-1

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