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The Sur1-Trpm4 channel regulates NOS2 transcription in TLR4-activated microglia

BACKGROUND: Harmful effects of activated microglia are due, in part, to the formation of peroxynitrite radicals, which is attributable to the upregulation of inducible nitric oxide (NO) synthase (NOS2). Because NOS2 expression is determined by Ca(2+)-sensitive calcineurin (CN) dephosphorylating nucl...

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Detalles Bibliográficos
Autores principales:	Kurland, David B., Gerzanich, Volodymyr, Karimy, Jason K., Woo, Seung Kyoon, Vennekens, Rudi, Freichel, Marc, Nilius, Bernd, Bryan, Joseph, Simard, J. Marc
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888589/ https://www.ncbi.nlm.nih.gov/pubmed/27246103 http://dx.doi.org/10.1186/s12974-016-0599-2

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