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The comparison of clinical and biological characteristics between IDH1 and IDH2 mutations in gliomas
BACKGROUND: Mutations in isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) are frequent in low-grade gliomas and secondary glioblastomas (sGBM). Because they yield the same oncometabolite, D-2-hydroxyglutarate, they are often treated as equivalent and pooled. The objective of t...
Autores principales: | Wang, Hao-Yuan, Tang, Kai, Liang, Ting-Yu, Zhang, Wei-Zhong, Li, Ji-Ye, Wang, Wen, Hu, Hui-Min, Li, Ming-Yang, Wang, Hui-Qing, He, Xiao-Zheng, Zhu, Zhi-Yuan, Liu, Yan-Wei, Zhang, Shi-Zhong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888668/ https://www.ncbi.nlm.nih.gov/pubmed/27245697 http://dx.doi.org/10.1186/s13046-016-0362-7 |
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