Cargando…

Quantitative assessment of visual estimation of the infrared indocyanine green imaging of lymph nodes retrieved at sentinel node navigation surgery for gastric cancer

BACKGROUND: Although the infrared indocyanine green (ICG) imaging is an effective method to identify sentinel lymph nodes (SLNs) of gastric cancer, its objectivity has not been verified. METHODS: We studied 563 lymph nodes under infrared light observation from the ICG-positive lymphatic basins of 36...

Descripción completa

Detalles Bibliográficos
Autores principales: Takahashi, Naoto, Nimura, Hiroshi, Fujita, Tetsuji, Yamashita, Shigeo, Mitsumori, Norio, Yanaga, Katsuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888669/
https://www.ncbi.nlm.nih.gov/pubmed/27245664
http://dx.doi.org/10.1186/s12893-016-0152-3
_version_ 1782434886004506624
author Takahashi, Naoto
Nimura, Hiroshi
Fujita, Tetsuji
Yamashita, Shigeo
Mitsumori, Norio
Yanaga, Katsuhiko
author_facet Takahashi, Naoto
Nimura, Hiroshi
Fujita, Tetsuji
Yamashita, Shigeo
Mitsumori, Norio
Yanaga, Katsuhiko
author_sort Takahashi, Naoto
collection PubMed
description BACKGROUND: Although the infrared indocyanine green (ICG) imaging is an effective method to identify sentinel lymph nodes (SLNs) of gastric cancer, its objectivity has not been verified. METHODS: We studied 563 lymph nodes under infrared light observation from the ICG-positive lymphatic basins of 36 patients who underwent SLN-navigated gastrectomy for clinically node-negative gastric cancer. First, the rate of SLN detection, the number of SLNs and sensitivities were compared between ordinary light observation and infrared light observation. Second, 563 lymph nodes were grouped into ICG-positive and -negative under infrared light observation. The intensities of the region of interest for each lymph node defined as the lymph node on which digital imaging was performed using an imaging-software, and the region of reference defined as its surrounding background, were compared and quantified. RESULTS: In the comparison of ordinary light observation with infrared light observation, the SLN identification rates were 28/36 (78 %) vs. 36/36 (100 %), the mean ± SD (minimum to maximum) number of SLNs was 3.4 ± 3.7 (0–16) vs. 9.2 ± 5.9 (2–25), and the sensitivities were 1/5 (20 %) vs. 5/5 (100 %). The ICG-positive group contained 358 lymph nodes with an intensity of 0.323 ± 1.56 (mean ± SD), and the ICG-negative group contained 205 lymph nodes with an intensity of 0.639 ± 1.93 (mean ± SD), demonstrating a significant difference between these two groups (P < 0.0001). CONCLUSIONS: The significant difference in the intensity as measured by an imaging-software between ICG-positive and ICG-negative lymph nodes would erase the concern about the objectivity of the infrared ICG method for SLN-navigated surgery for early gastric cancer.
format Online
Article
Text
id pubmed-4888669
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-48886692016-06-02 Quantitative assessment of visual estimation of the infrared indocyanine green imaging of lymph nodes retrieved at sentinel node navigation surgery for gastric cancer Takahashi, Naoto Nimura, Hiroshi Fujita, Tetsuji Yamashita, Shigeo Mitsumori, Norio Yanaga, Katsuhiko BMC Surg Research Article BACKGROUND: Although the infrared indocyanine green (ICG) imaging is an effective method to identify sentinel lymph nodes (SLNs) of gastric cancer, its objectivity has not been verified. METHODS: We studied 563 lymph nodes under infrared light observation from the ICG-positive lymphatic basins of 36 patients who underwent SLN-navigated gastrectomy for clinically node-negative gastric cancer. First, the rate of SLN detection, the number of SLNs and sensitivities were compared between ordinary light observation and infrared light observation. Second, 563 lymph nodes were grouped into ICG-positive and -negative under infrared light observation. The intensities of the region of interest for each lymph node defined as the lymph node on which digital imaging was performed using an imaging-software, and the region of reference defined as its surrounding background, were compared and quantified. RESULTS: In the comparison of ordinary light observation with infrared light observation, the SLN identification rates were 28/36 (78 %) vs. 36/36 (100 %), the mean ± SD (minimum to maximum) number of SLNs was 3.4 ± 3.7 (0–16) vs. 9.2 ± 5.9 (2–25), and the sensitivities were 1/5 (20 %) vs. 5/5 (100 %). The ICG-positive group contained 358 lymph nodes with an intensity of 0.323 ± 1.56 (mean ± SD), and the ICG-negative group contained 205 lymph nodes with an intensity of 0.639 ± 1.93 (mean ± SD), demonstrating a significant difference between these two groups (P < 0.0001). CONCLUSIONS: The significant difference in the intensity as measured by an imaging-software between ICG-positive and ICG-negative lymph nodes would erase the concern about the objectivity of the infrared ICG method for SLN-navigated surgery for early gastric cancer. BioMed Central 2016-06-01 /pmc/articles/PMC4888669/ /pubmed/27245664 http://dx.doi.org/10.1186/s12893-016-0152-3 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Takahashi, Naoto
Nimura, Hiroshi
Fujita, Tetsuji
Yamashita, Shigeo
Mitsumori, Norio
Yanaga, Katsuhiko
Quantitative assessment of visual estimation of the infrared indocyanine green imaging of lymph nodes retrieved at sentinel node navigation surgery for gastric cancer
title Quantitative assessment of visual estimation of the infrared indocyanine green imaging of lymph nodes retrieved at sentinel node navigation surgery for gastric cancer
title_full Quantitative assessment of visual estimation of the infrared indocyanine green imaging of lymph nodes retrieved at sentinel node navigation surgery for gastric cancer
title_fullStr Quantitative assessment of visual estimation of the infrared indocyanine green imaging of lymph nodes retrieved at sentinel node navigation surgery for gastric cancer
title_full_unstemmed Quantitative assessment of visual estimation of the infrared indocyanine green imaging of lymph nodes retrieved at sentinel node navigation surgery for gastric cancer
title_short Quantitative assessment of visual estimation of the infrared indocyanine green imaging of lymph nodes retrieved at sentinel node navigation surgery for gastric cancer
title_sort quantitative assessment of visual estimation of the infrared indocyanine green imaging of lymph nodes retrieved at sentinel node navigation surgery for gastric cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888669/
https://www.ncbi.nlm.nih.gov/pubmed/27245664
http://dx.doi.org/10.1186/s12893-016-0152-3
work_keys_str_mv AT takahashinaoto quantitativeassessmentofvisualestimationoftheinfraredindocyaninegreenimagingoflymphnodesretrievedatsentinelnodenavigationsurgeryforgastriccancer
AT nimurahiroshi quantitativeassessmentofvisualestimationoftheinfraredindocyaninegreenimagingoflymphnodesretrievedatsentinelnodenavigationsurgeryforgastriccancer
AT fujitatetsuji quantitativeassessmentofvisualestimationoftheinfraredindocyaninegreenimagingoflymphnodesretrievedatsentinelnodenavigationsurgeryforgastriccancer
AT yamashitashigeo quantitativeassessmentofvisualestimationoftheinfraredindocyaninegreenimagingoflymphnodesretrievedatsentinelnodenavigationsurgeryforgastriccancer
AT mitsumorinorio quantitativeassessmentofvisualestimationoftheinfraredindocyaninegreenimagingoflymphnodesretrievedatsentinelnodenavigationsurgeryforgastriccancer
AT yanagakatsuhiko quantitativeassessmentofvisualestimationoftheinfraredindocyaninegreenimagingoflymphnodesretrievedatsentinelnodenavigationsurgeryforgastriccancer