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Clinicopathological and prognostic significance of sialyl Lewis X overexpression in patients with cancer: a meta-analysis

Many studies have shown that sialyl Lewis X (sLe(X)) is related to cancer prognosis and clinicopathology, but failed to provide conclusive results. We conducted the present meta-analysis to identify the association between sLe(X) overexpression and cancer prognosis. We searched studies in PubMed and...

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Autores principales: Liang, Jin-xiao, Liang, Yong, Gao, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888715/
https://www.ncbi.nlm.nih.gov/pubmed/27307752
http://dx.doi.org/10.2147/OTT.S102389
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author Liang, Jin-xiao
Liang, Yong
Gao, Wei
author_facet Liang, Jin-xiao
Liang, Yong
Gao, Wei
author_sort Liang, Jin-xiao
collection PubMed
description Many studies have shown that sialyl Lewis X (sLe(X)) is related to cancer prognosis and clinicopathology, but failed to provide conclusive results. We conducted the present meta-analysis to identify the association between sLe(X) overexpression and cancer prognosis. We searched studies in PubMed and Embase databases. Relative risk or hazard ratio with 95% confidence intervals were estimated with the Mantel–Haenszel random-effect method and 29 studies were included. Our meta-analysis showed that sLe(X) overexpression is significantly related to lymphatic invasion, venous invasion, T stage, N stage, M stage, tumor stage, recurrence, and overall survival. In subgroup analysis, we found that cancer type and ethnicity might be two major contributing factors to the possible presence of heterogeneity among the studies. In conclusion, sLe(X) overexpression is associated with tumor metastasis, recurrence, and overall survival in cancer patients, it plays an important role in cancer prognosis.
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spelling pubmed-48887152016-06-15 Clinicopathological and prognostic significance of sialyl Lewis X overexpression in patients with cancer: a meta-analysis Liang, Jin-xiao Liang, Yong Gao, Wei Onco Targets Ther Original Research Many studies have shown that sialyl Lewis X (sLe(X)) is related to cancer prognosis and clinicopathology, but failed to provide conclusive results. We conducted the present meta-analysis to identify the association between sLe(X) overexpression and cancer prognosis. We searched studies in PubMed and Embase databases. Relative risk or hazard ratio with 95% confidence intervals were estimated with the Mantel–Haenszel random-effect method and 29 studies were included. Our meta-analysis showed that sLe(X) overexpression is significantly related to lymphatic invasion, venous invasion, T stage, N stage, M stage, tumor stage, recurrence, and overall survival. In subgroup analysis, we found that cancer type and ethnicity might be two major contributing factors to the possible presence of heterogeneity among the studies. In conclusion, sLe(X) overexpression is associated with tumor metastasis, recurrence, and overall survival in cancer patients, it plays an important role in cancer prognosis. Dove Medical Press 2016-05-24 /pmc/articles/PMC4888715/ /pubmed/27307752 http://dx.doi.org/10.2147/OTT.S102389 Text en © 2016 Liang et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Liang, Jin-xiao
Liang, Yong
Gao, Wei
Clinicopathological and prognostic significance of sialyl Lewis X overexpression in patients with cancer: a meta-analysis
title Clinicopathological and prognostic significance of sialyl Lewis X overexpression in patients with cancer: a meta-analysis
title_full Clinicopathological and prognostic significance of sialyl Lewis X overexpression in patients with cancer: a meta-analysis
title_fullStr Clinicopathological and prognostic significance of sialyl Lewis X overexpression in patients with cancer: a meta-analysis
title_full_unstemmed Clinicopathological and prognostic significance of sialyl Lewis X overexpression in patients with cancer: a meta-analysis
title_short Clinicopathological and prognostic significance of sialyl Lewis X overexpression in patients with cancer: a meta-analysis
title_sort clinicopathological and prognostic significance of sialyl lewis x overexpression in patients with cancer: a meta-analysis
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888715/
https://www.ncbi.nlm.nih.gov/pubmed/27307752
http://dx.doi.org/10.2147/OTT.S102389
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