HIF-1α and HIF-2α induced angiogenesis in gastrointestinal vascular malformation and reversed by thalidomide

Thalidomide is used in clinical practice to treat gastrointestinal vascular malformation (GIVM), but the pathogenesis of GIVM is not clear. Hypoxia inducible factor 1 alpha (HIF-1α) and 2 alpha (HIF-2α/EPAS1) are in the same family and act as master regulators of the adaptive response to hypoxia. HI...

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Detalles Bibliográficos
Autores principales: Feng, Nan, Chen, Haiying, Fu, Sengwang, Bian, Zhaolian, Lin, Xiaolu, Yang, Li, Gao, Yunjie, Fang, Jingyuan, Ge, Zhizheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888746/
https://www.ncbi.nlm.nih.gov/pubmed/27249651
http://dx.doi.org/10.1038/srep27280

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