Cargando…
The origin of the cooperativity in the streptavidin-biotin system: A computational investigation through molecular dynamics simulations
Previous experimental study measuring the binding affinities of biotin to the wild type streptavidin (WT) and three mutants (S45A, D128A and S45A/D128A double mutant) has shown that the loss of binding affinity from the double mutation is larger than the direct sum of those from two single mutations...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888747/ https://www.ncbi.nlm.nih.gov/pubmed/27249234 http://dx.doi.org/10.1038/srep27190 |