Physiological restraint of Bak by Bcl-x(L) is essential for cell survival

Due to the myriad interactions between prosurvival and proapoptotic members of the Bcl-2 family of proteins, establishing the mechanisms that regulate the intrinsic apoptotic pathway has proven challenging. Mechanistic insights have primarily been gleaned from in vitro studies because genetic approa...

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Detalles Bibliográficos
Autores principales: Lee, Erinna F., Grabow, Stephanie, Chappaz, Stephane, Dewson, Grant, Hockings, Colin, Kluck, Ruth M., Debrincat, Marlyse A., Gray, Daniel H., Witkowski, Matthew T., Evangelista, Marco, Pettikiriarachchi, Anne, Bouillet, Philippe, Lane, Rachael M., Czabotar, Peter E., Colman, Peter M., Smith, Brian J., Kile, Benjamin T., Fairlie, W. Douglas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888843/
https://www.ncbi.nlm.nih.gov/pubmed/27198225
http://dx.doi.org/10.1101/gad.279414.116

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