Mutations in Encephalomyocarditis Virus 3A Protein Uncouple the Dependency of Genome Replication on Host Factors Phosphatidylinositol 4-Kinase IIIα and Oxysterol-Binding Protein

Positive-strand RNA [(+)RNA] viruses are true masters of reprogramming host lipid trafficking and synthesis to support virus genome replication. Via their membrane-associated 3A protein, picornaviruses of the genus Enterovirus (e.g., poliovirus, coxsackievirus, and rhinovirus) subvert Golgi complex-...

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Detalles Bibliográficos
Autores principales: Dorobantu, Cristina M., Albulescu, Lucian, Lyoo, Heyrhyoung, van Kampen, Mirjam, De Francesco, Raffaele, Lohmann, Volker, Harak, Christian, van der Schaar, Hilde M., Strating, Jeroen R. P. M., Gorbalenya, Alexander E., van Kuppeveld, Frank J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888891/
https://www.ncbi.nlm.nih.gov/pubmed/27303747
http://dx.doi.org/10.1128/mSphere.00068-16

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