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Three-dimensional printing of the retina

PURPOSE OF REVIEW: Biological three-dimensional printing has received a lot of media attention over recent years with advances made in printing cellular structures, including skin and heart tissue for transplantation. Although limitations exist in creating functioning organs with this method, the ho...

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Autores principales: Lorber, Barbara, Hsiao, Wen-Kai, Martin, Keith R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888916/
https://www.ncbi.nlm.nih.gov/pubmed/27045545
http://dx.doi.org/10.1097/ICU.0000000000000252
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author Lorber, Barbara
Hsiao, Wen-Kai
Martin, Keith R.
author_facet Lorber, Barbara
Hsiao, Wen-Kai
Martin, Keith R.
author_sort Lorber, Barbara
collection PubMed
description PURPOSE OF REVIEW: Biological three-dimensional printing has received a lot of media attention over recent years with advances made in printing cellular structures, including skin and heart tissue for transplantation. Although limitations exist in creating functioning organs with this method, the hope has been raised that creating a functional retina to cure blindness is within reach. The present review provides an update on the advances made toward this goal. RECENT FINDINGS: It has recently been shown that two types of retinal cells, retinal ganglion cells and glial cells, can be successfully printed using a piezoelectric inkjet printer. Importantly, the cells remained viable and did not change certain phenotypic features as a result of the printing process. In addition, recent advances in the creation of complex and viable three-dimensional cellular structures have been made. SUMMARY: Some first promising steps toward the creation of a functional retina have been taken. It now needs to be investigated whether recent findings can be extended to other cells of the retina, including those derived from human tissue, and if a complex and viable retinal structure can be created through three-dimensional printing.
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spelling pubmed-48889162016-07-26 Three-dimensional printing of the retina Lorber, Barbara Hsiao, Wen-Kai Martin, Keith R. Curr Opin Ophthalmol TRANSLATIONAL RESEARCH: Edited by Jason Hsu and Sunir J. Garg PURPOSE OF REVIEW: Biological three-dimensional printing has received a lot of media attention over recent years with advances made in printing cellular structures, including skin and heart tissue for transplantation. Although limitations exist in creating functioning organs with this method, the hope has been raised that creating a functional retina to cure blindness is within reach. The present review provides an update on the advances made toward this goal. RECENT FINDINGS: It has recently been shown that two types of retinal cells, retinal ganglion cells and glial cells, can be successfully printed using a piezoelectric inkjet printer. Importantly, the cells remained viable and did not change certain phenotypic features as a result of the printing process. In addition, recent advances in the creation of complex and viable three-dimensional cellular structures have been made. SUMMARY: Some first promising steps toward the creation of a functional retina have been taken. It now needs to be investigated whether recent findings can be extended to other cells of the retina, including those derived from human tissue, and if a complex and viable retinal structure can be created through three-dimensional printing. Lippincott Williams & Wilkins 2016-05 2016-04-07 /pmc/articles/PMC4888916/ /pubmed/27045545 http://dx.doi.org/10.1097/ICU.0000000000000252 Text en Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution-Non Commercial License 4.0, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be used commercially. http://creativecommons.org/licenses/by/4.0
spellingShingle TRANSLATIONAL RESEARCH: Edited by Jason Hsu and Sunir J. Garg
Lorber, Barbara
Hsiao, Wen-Kai
Martin, Keith R.
Three-dimensional printing of the retina
title Three-dimensional printing of the retina
title_full Three-dimensional printing of the retina
title_fullStr Three-dimensional printing of the retina
title_full_unstemmed Three-dimensional printing of the retina
title_short Three-dimensional printing of the retina
title_sort three-dimensional printing of the retina
topic TRANSLATIONAL RESEARCH: Edited by Jason Hsu and Sunir J. Garg
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888916/
https://www.ncbi.nlm.nih.gov/pubmed/27045545
http://dx.doi.org/10.1097/ICU.0000000000000252
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