GSH-dependent antioxidant defense contributes to the acclimation of colon cancer cells to acidic microenvironment

Due to increased glycolysis and poor local perfusion, solid tumors are usually immersed in an acidic microenvironment. While extracellular acidosis is cytotoxic, cancer cells eventually become acclimated to it. While previous studies have addressed the acute effect of acidosis on cancer cells, littl...

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Detalles Bibliográficos
Autores principales: Zhao, Minnan, Liu, Qiao, Gong, Yanchao, Xu, Xiuhua, Zhang, Chen, Liu, Xiaojie, Zhang, Caibo, Guo, Haiyang, Zhang, Xiyu, Gong, Yaoqin, Shao, Changshun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889284/
https://www.ncbi.nlm.nih.gov/pubmed/26950675
http://dx.doi.org/10.1080/15384101.2016.1158374

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