Cargando…

Selective protein degradation ensures cellular longevity

A previously unknown pathway can selectively degrade mitochondrial proteins in aged and stressed cells without destroying the organelle itself.

Detalles Bibliográficos
Autores principales:	Malmgren Hill, Sandra, Nyström, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2016
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889324/ https://www.ncbi.nlm.nih.gov/pubmed/27247277 http://dx.doi.org/10.7554/eLife.17185

Ejemplares similares

Protein Phosphatase 1 inactivates Mps1 to ensure efficient Spindle Assembly Checkpoint silencing
por: Moura, Margarida, et al.
Publicado: (2017)

The equatorial position of the metaphase plate ensures symmetric cell divisions
por: Tan, Chia Huei, et al.
Publicado: (2015)

The linker domain of the SNARE protein SNAP25 acts as a flexible molecular spacer that ensures efficient S-acylation
por: Salaun, Christine, et al.
Publicado: (2020)

Photoreceptor disc incisures form as an adaptive mechanism ensuring the completion of disc enclosure
por: Lewis, Tylor R, et al.
Publicado: (2023)

Stressing about misplaced fat is a key to longevity
por: Lemieux, George A, et al.
Publicado: (2015)

Telomeric double-strand DNA-binding proteins DTN-1 and DTN-2 ensure germline immortality in Caenorhabditis elegans
por: Yamamoto, Io, et al.
Publicado: (2021)

Reliable cell cycle commitment in budding yeast is ensured by signal integration
por: Liu, Xili, et al.
Publicado: (2015)

Serotonin signaling by maternal neurons upon stress ensures progeny survival
por: Das, Srijit, et al.
Publicado: (2020)

Physically asymmetric division of the C. elegans zygote ensures invariably successful embryogenesis
por: Jankele, Radek, et al.
Publicado: (2021)

A feedback loop governs the relationship between lipid metabolism and longevity
por: Littlejohn, Nicole K, et al.
Publicado: (2020)

Multiple inputs ensure yeast cell size homeostasis during cell cycle progression
por: Garmendia-Torres, Cecilia, et al.
Publicado: (2018)

Endoplasmic reticulum-associated SKN-1A/Nrf1 mediates a cytoplasmic unfolded protein response and promotes longevity
por: Lehrbach, Nicolas J, et al.
Publicado: (2019)

Quantitative glycoproteomics reveals cellular substrate selectivity of the ER protein quality control sensors UGGT1 and UGGT2
por: Adams, Benjamin M, et al.
Publicado: (2020)

Endogenous siRNAs promote proteostasis and longevity in germline-less Caenorhabditis elegans
por: Cohen-Berkman, Moran, et al.
Publicado: (2020)

Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans
por: Sun, Yanan, et al.
Publicado: (2020)

Concerted action of neuroepithelial basal shrinkage and active epithelial migration ensures efficient optic cup morphogenesis
por: Sidhaye, Jaydeep, et al.
Publicado: (2017)

Kinetochores attached to microtubule-ends are stabilised by Astrin bound PP1 to ensure proper chromosome segregation
por: Conti, Duccio, et al.
Publicado: (2019)

Cytoskeletal tension and Bazooka tune interface geometry to ensure fusion fidelity and sheet integrity during dorsal closure
por: Das Gupta, Piyal Taru, et al.
Publicado: (2019)

MCMBP promotes the assembly of the MCM2–7 hetero-hexamer to ensure robust DNA replication in human cells
por: Saito, Yuichiro, et al.
Publicado: (2022)

Endoplasmic reticulum stress and the protein degradation system in ophthalmic diseases
por: Song, Jing-Yao, et al.
Publicado: (2020)

Emerging Roles of the Intraflagellar Transport System in the Orchestration of Cellular Degradation Pathways
por: Finetti, Francesca, et al.
Publicado: (2019)

Restricted access: spatial sequestration of damaged proteins during stress and aging
por: Hill, Sandra Malmgren, et al.
Publicado: (2017)

Cell culture-based profiling across mammals reveals DNA repair and metabolism as determinants of species longevity
por: Ma, Siming, et al.
Publicado: (2016)

Heat stress promotes longevity in budding yeast by relaxing the confinement of age-promoting factors in the mother cell
por: Baldi, Sandro, et al.
Publicado: (2017)

Epigenetic drift of H3K27me3 in aging links glycolysis to healthy longevity in Drosophila
por: Ma, Zaijun, et al.
Publicado: (2018)

Confluence of Cellular Degradation Pathways During Interdigital Tissue Remodeling in Embryonic Tetrapods
por: Montero, Juan A., et al.
Publicado: (2020)

Casein kinase 1 family proteins promote Slimb-dependent Expanded degradation
por: Fulford, Alexander D, et al.
Publicado: (2019)

Luciferase-LOV BRET enables versatile and specific transcriptional readout of cellular protein-protein interactions
por: Kim, Christina K, et al.
Publicado: (2019)

Hsp90 (Heat Shock Protein 90) Inhibitor Occupancy Is a Direct Determinant of Client Protein Degradation and Tumor Growth Arrest in Vivo
por: Tillotson, Bonnie, et al.
Publicado: (2010)

Glucose Deprivation Triggers Protein Kinase C-dependent β-Catenin Proteasomal Degradation
por: Choi, Seung-Won, et al.
Publicado: (2015)

Degradative and Non-Degradative Roles of Autophagy Proteins in Metabolism and Metabolic Diseases
por: Kuramoto, Kenta, et al.
Publicado: (2022)

Maximizing Longevity and Healthspan: Multiple Approaches All Converging on Autophagy
por: Bareja, Akshay, et al.
Publicado: (2019)

Effect of Metformin on Cardiac Metabolism and Longevity in Aged Female Mice
por: Zhu, Xudong, et al.
Publicado: (2021)

The ensured proliferative capacity of myoblast in serum-reduced conditions with Methyl-β-cyclodextrin
por: Katayama, Tomoka, et al.
Publicado: (2023)

Identification of a Lysosomal Pathway Regulating Degradation of the Bone Morphogenetic Protein Receptor Type II
por: Durrington, Hannah J., et al.
Publicado: (2010)

The dual role of a yeast metacaspase: What doesn't kill you makes you stronger
por: Hill, Sandra Malmgren, et al.
Publicado: (2015)

A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair
por: Velasco-Aviles, Sergio, et al.
Publicado: (2022)

Longevity is impacted by growth hormone action during early postnatal period
por: Sun, Liou Y, et al.
Publicado: (2017)

Small Molecule-facilitated Degradation of ANO1 Protein: A NEW TARGETING APPROACH FOR ANTICANCER THERAPEUTICS
por: Bill, Anke, et al.
Publicado: (2014)

Disparate bone anabolic cues activate bone formation by regulating the rapid lysosomal degradation of sclerostin protein
por: Gould, Nicole R, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_jlvjq516s1atp2532raf0oask9