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The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids

The mechanistic Target of Rapamycin complex 1 (mTORC1) senses intracellular amino acid levels through an intricate machinery, which includes the Rag GTPases, Ragulator and vacuolar ATPase (V-ATPase). The membrane-associated E3 ubiquitin ligase ZNRF2 is released into the cytosol upon its phosphorylat...

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Detalles Bibliográficos
Autores principales:	Hoxhaj, Gerta, Caddye, Edward, Najafov, Ayaz, Houde, Vanessa P, Johnson, Catherine, Dissanayake, Kumara, Toth, Rachel, Campbell, David G, Prescott, Alan R, MacKintosh, Carol
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2016
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889327/ https://www.ncbi.nlm.nih.gov/pubmed/27244671 http://dx.doi.org/10.7554/eLife.12278

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