PI(3,5)P(2) biosynthesis regulates oligodendrocyte differentiation by intrinsic and extrinsic mechanisms

Proper development of the CNS axon-glia unit requires bi-directional communication between axons and oligodendrocytes (OLs). We show that the signaling lipid phosphatidylinositol-3,5-bisphosphate [PI(3,5)P(2)] is required in neurons and in OLs for normal CNS myelination. In mice, mutations of Fig4,...

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Detalles Bibliográficos
Autores principales: Mironova, Yevgeniya A, Lenk, Guy M, Lin, Jing-Ping, Lee, Seung Joon, Twiss, Jeffery L, Vaccari, Ilaria, Bolino, Alessandra, Havton, Leif A, Min, Sang H, Abrams, Charles S, Shrager, Peter, Meisler, Miriam H, Giger, Roman J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889328/
https://www.ncbi.nlm.nih.gov/pubmed/27008179
http://dx.doi.org/10.7554/eLife.13023

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