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Targeting the PI3K/Akt pathway in murine MDS/MPN driven by hyperactive Ras

Chronic and juvenile myelomonocytic leukemias (CMML and JMML) are myelodysplastic/myeloproliferative neoplasia (MDS/MPN) overlap syndromes that respond poorly to conventional treatments. Aberrant Ras activation due to NRAS, KRAS, PTPN11, CBL, and NF1 mutations is common in CMML and JMML. However, no...

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Detalles Bibliográficos
Autores principales:	Akutagawa, Jon, Huang, Tannie Q., Epstein, Inbal, Chang, Tiffany, Quirindongo-Crespo, Maricel, Cottonham, Charisa L., Dail, Monique, Slusher, Barbara S., Friedman, Lori S., Sampath, Deepak, Braun, Benjamin S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889473/ https://www.ncbi.nlm.nih.gov/pubmed/26965285 http://dx.doi.org/10.1038/leu.2016.14

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