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Mechanism of human rhinovirus infections

About 150 human rhinovirus serotypes are responsible for more than 50 % of recurrent upper respiratory infections. Despite having similar 3D structures, some bind members of the low-density lipoprotein receptor family, some ICAM-1, and some use CDHR3 for host cell infection. This is also reflected i...

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Detalles Bibliográficos
Autores principales: Blaas, Dieter, Fuchs, Renate
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889530/
https://www.ncbi.nlm.nih.gov/pubmed/27251607
http://dx.doi.org/10.1186/s40348-016-0049-3
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author Blaas, Dieter
Fuchs, Renate
author_facet Blaas, Dieter
Fuchs, Renate
author_sort Blaas, Dieter
collection PubMed
description About 150 human rhinovirus serotypes are responsible for more than 50 % of recurrent upper respiratory infections. Despite having similar 3D structures, some bind members of the low-density lipoprotein receptor family, some ICAM-1, and some use CDHR3 for host cell infection. This is also reflected in the pathways exploited for cellular entry. We found that even rhinovirus serotypes binding the same receptor can travel along different endocytic pathways and release their RNA genome into the cytosol at different locations. How this may account for distinct immune responses elicited by various rhinoviruses and the observed symptoms of the common cold is briefly discussed.
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spelling pubmed-48895302016-06-17 Mechanism of human rhinovirus infections Blaas, Dieter Fuchs, Renate Mol Cell Pediatr Mini Review About 150 human rhinovirus serotypes are responsible for more than 50 % of recurrent upper respiratory infections. Despite having similar 3D structures, some bind members of the low-density lipoprotein receptor family, some ICAM-1, and some use CDHR3 for host cell infection. This is also reflected in the pathways exploited for cellular entry. We found that even rhinovirus serotypes binding the same receptor can travel along different endocytic pathways and release their RNA genome into the cytosol at different locations. How this may account for distinct immune responses elicited by various rhinoviruses and the observed symptoms of the common cold is briefly discussed. Springer Berlin Heidelberg 2016-06-01 /pmc/articles/PMC4889530/ /pubmed/27251607 http://dx.doi.org/10.1186/s40348-016-0049-3 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Mini Review
Blaas, Dieter
Fuchs, Renate
Mechanism of human rhinovirus infections
title Mechanism of human rhinovirus infections
title_full Mechanism of human rhinovirus infections
title_fullStr Mechanism of human rhinovirus infections
title_full_unstemmed Mechanism of human rhinovirus infections
title_short Mechanism of human rhinovirus infections
title_sort mechanism of human rhinovirus infections
topic Mini Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889530/
https://www.ncbi.nlm.nih.gov/pubmed/27251607
http://dx.doi.org/10.1186/s40348-016-0049-3
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