A Pathway Switch Directs BAFF Signaling to Distinct NFκB Transcription Factors in Maturing and Proliferating B Cells

BAFF, an activator of the noncanonical NFκB pathway, provides critical survival signals during B cell maturation and contributes to B cell proliferation. We found that the NFκB family member RelB is required ex vivo for B cell maturation, but cRel is required for proliferation. Combined molecular ne...

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Detalles Bibliográficos
Autores principales: Almaden, Jonathan V., Tsui, Rachel, Liu, Yi C., Birnbaum, Harry, Shokhirev, Maxim N., Ngo, Kim A., Davis-Turak, Jeremy C., Otero, Dennis, Basak, Soumen, Rickert, Robert C., Hoffmann, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889572/
https://www.ncbi.nlm.nih.gov/pubmed/25497099
http://dx.doi.org/10.1016/j.celrep.2014.11.024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889572/
https://www.ncbi.nlm.nih.gov/pubmed/25497099
http://dx.doi.org/10.1016/j.celrep.2014.11.024

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