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N-Ethyl-N-Nitrosourea (ENU) Mutagenesis Reveals an Intronic Residue Critical for Caenorhabditis elegans 3′ Splice Site Function in Vivo

Metazoan introns contain a polypyrimidine tract immediately upstream of the AG dinucleotide that defines the 3′ splice site. In the nematode Caenorhabditis elegans, 3′ splice sites are characterized by a highly conserved UUUUCAG/R octamer motif. While the conservation of pyrimidines in this motif is...

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Detalles Bibliográficos
Autores principales:	Itani, Omar A., Flibotte, Stephane, Dumas, Kathleen J., Guo, Chunfang, Blumenthal, Thomas, Hu, Patrick J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Genetics Society of America 2016
Materias:	Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889670/ https://www.ncbi.nlm.nih.gov/pubmed/27172199 http://dx.doi.org/10.1534/g3.116.028662

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