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ESP-102, a Combined Herbal Extract of Angelica gigas, Saururus chinensis, and Schisandra chinensis, Changes Synaptic Plasticity and Attenuates Scopolamine-Induced Memory Impairment in Rat Hippocampus Tissue

ESP-102, an extract from Angelica gigas, Saururus chinensis, and Schisandra chinensis, has been used as herbal medicine and dietary supplement in Korea. Despite the numerous bioactivities in vitro and in vivo studies, its effects on neuronal networks remain elusive. To address the neuronal effect, w...

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Autores principales: Kim, Hyun-Bum, Hwang, Eun-Sang, Choi, Ga-Young, Lee, Seok, Park, Tae-Suk, Lee, Cheol-Won, Lee, Eun-Suk, Kim, Young-Choong, Kim, Sang Seong, Lee, Sung-Ok, Park, Ji-Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889857/
https://www.ncbi.nlm.nih.gov/pubmed/27298627
http://dx.doi.org/10.1155/2016/8793095
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author Kim, Hyun-Bum
Hwang, Eun-Sang
Choi, Ga-Young
Lee, Seok
Park, Tae-Suk
Lee, Cheol-Won
Lee, Eun-Suk
Kim, Young-Choong
Kim, Sang Seong
Lee, Sung-Ok
Park, Ji-Ho
author_facet Kim, Hyun-Bum
Hwang, Eun-Sang
Choi, Ga-Young
Lee, Seok
Park, Tae-Suk
Lee, Cheol-Won
Lee, Eun-Suk
Kim, Young-Choong
Kim, Sang Seong
Lee, Sung-Ok
Park, Ji-Ho
author_sort Kim, Hyun-Bum
collection PubMed
description ESP-102, an extract from Angelica gigas, Saururus chinensis, and Schisandra chinensis, has been used as herbal medicine and dietary supplement in Korea. Despite the numerous bioactivities in vitro and in vivo studies, its effects on neuronal networks remain elusive. To address the neuronal effect, we examined synaptic plasticity in organotypic hippocampal slice culture with multielectrode array. Our results showed an increase in excitatory postsynaptic potential (EPSP), indicating the induction of long-term potentiation (LTP), in the presence of ESP-102. In addition, the neuroprotective effect of ESP-102 was also tested by application of scopolamine to the hippocampal slice. Interestingly, ESP-102 competitively antagonized the preventative LTP effect induced by scopolamine. The scopolamine-induced reduction in brain-derived neurotrophic factor (BDNF) and GluR-2 expression was also rescued by ESP-102. In terms of mode of action, ESP-102 appears to act on the presynaptic region independent of AMPA/NMDA receptors. Based on these findings, ESP-102 can be suggested as a novel herbal ingredient with memory enhancing as well as neuroprotective effects.
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spelling pubmed-48898572016-06-13 ESP-102, a Combined Herbal Extract of Angelica gigas, Saururus chinensis, and Schisandra chinensis, Changes Synaptic Plasticity and Attenuates Scopolamine-Induced Memory Impairment in Rat Hippocampus Tissue Kim, Hyun-Bum Hwang, Eun-Sang Choi, Ga-Young Lee, Seok Park, Tae-Suk Lee, Cheol-Won Lee, Eun-Suk Kim, Young-Choong Kim, Sang Seong Lee, Sung-Ok Park, Ji-Ho Evid Based Complement Alternat Med Research Article ESP-102, an extract from Angelica gigas, Saururus chinensis, and Schisandra chinensis, has been used as herbal medicine and dietary supplement in Korea. Despite the numerous bioactivities in vitro and in vivo studies, its effects on neuronal networks remain elusive. To address the neuronal effect, we examined synaptic plasticity in organotypic hippocampal slice culture with multielectrode array. Our results showed an increase in excitatory postsynaptic potential (EPSP), indicating the induction of long-term potentiation (LTP), in the presence of ESP-102. In addition, the neuroprotective effect of ESP-102 was also tested by application of scopolamine to the hippocampal slice. Interestingly, ESP-102 competitively antagonized the preventative LTP effect induced by scopolamine. The scopolamine-induced reduction in brain-derived neurotrophic factor (BDNF) and GluR-2 expression was also rescued by ESP-102. In terms of mode of action, ESP-102 appears to act on the presynaptic region independent of AMPA/NMDA receptors. Based on these findings, ESP-102 can be suggested as a novel herbal ingredient with memory enhancing as well as neuroprotective effects. Hindawi Publishing Corporation 2016 2016-05-19 /pmc/articles/PMC4889857/ /pubmed/27298627 http://dx.doi.org/10.1155/2016/8793095 Text en Copyright © 2016 Hyun-Bum Kim et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kim, Hyun-Bum
Hwang, Eun-Sang
Choi, Ga-Young
Lee, Seok
Park, Tae-Suk
Lee, Cheol-Won
Lee, Eun-Suk
Kim, Young-Choong
Kim, Sang Seong
Lee, Sung-Ok
Park, Ji-Ho
ESP-102, a Combined Herbal Extract of Angelica gigas, Saururus chinensis, and Schisandra chinensis, Changes Synaptic Plasticity and Attenuates Scopolamine-Induced Memory Impairment in Rat Hippocampus Tissue
title ESP-102, a Combined Herbal Extract of Angelica gigas, Saururus chinensis, and Schisandra chinensis, Changes Synaptic Plasticity and Attenuates Scopolamine-Induced Memory Impairment in Rat Hippocampus Tissue
title_full ESP-102, a Combined Herbal Extract of Angelica gigas, Saururus chinensis, and Schisandra chinensis, Changes Synaptic Plasticity and Attenuates Scopolamine-Induced Memory Impairment in Rat Hippocampus Tissue
title_fullStr ESP-102, a Combined Herbal Extract of Angelica gigas, Saururus chinensis, and Schisandra chinensis, Changes Synaptic Plasticity and Attenuates Scopolamine-Induced Memory Impairment in Rat Hippocampus Tissue
title_full_unstemmed ESP-102, a Combined Herbal Extract of Angelica gigas, Saururus chinensis, and Schisandra chinensis, Changes Synaptic Plasticity and Attenuates Scopolamine-Induced Memory Impairment in Rat Hippocampus Tissue
title_short ESP-102, a Combined Herbal Extract of Angelica gigas, Saururus chinensis, and Schisandra chinensis, Changes Synaptic Plasticity and Attenuates Scopolamine-Induced Memory Impairment in Rat Hippocampus Tissue
title_sort esp-102, a combined herbal extract of angelica gigas, saururus chinensis, and schisandra chinensis, changes synaptic plasticity and attenuates scopolamine-induced memory impairment in rat hippocampus tissue
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889857/
https://www.ncbi.nlm.nih.gov/pubmed/27298627
http://dx.doi.org/10.1155/2016/8793095
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