Autocrine Acetylcholine, Induced by IL-17A via NFκB and ERK1/2 Pathway Activation, Promotes MUC5AC and IL-8 Synthesis in Bronchial Epithelial Cells

IL-17A is overexpressed in the lung during acute neutrophilic inflammation. Acetylcholine (ACh) increases IL-8 and Muc5AC production in airway epithelial cells. We aimed to characterize the involvement of nonneuronal components of cholinergic system on IL-8 and Muc5AC production in bronchial epithel...

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Detalles Bibliográficos
Autores principales: Montalbano, Angela Marina, Albano, Giusy Daniela, Bonanno, Anna, Riccobono, Loredana, Di Sano, Caterina, Ferraro, Maria, Siena, Liboria, Anzalone, Giulia, Gagliardo, Rosalia, Pieper, Michael Paul, Gjomarkaj, Mark, Profita, Mirella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889862/
https://www.ncbi.nlm.nih.gov/pubmed/27298519
http://dx.doi.org/10.1155/2016/9063842

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