New origin firing is inhibited by APC/C(Cdh1) activation in S-phase after severe replication stress

Defects in DNA replication and repair are known to promote genomic instability, a hallmark of cancer cells. Thus, eukaryotic cells have developed complex mechanisms to ensure accurate duplication of their genomes. While DNA damage response has been extensively studied in tumour cells, the pathways i...

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Detalles Bibliográficos
Autores principales: Ercilla, Amaia, Llopis, Alba, Feu, Sonia, Aranda, Sergi, Ernfors, Patrik, Freire, Raimundo, Agell, Neus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889930/
https://www.ncbi.nlm.nih.gov/pubmed/26939887
http://dx.doi.org/10.1093/nar/gkw132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889930/
https://www.ncbi.nlm.nih.gov/pubmed/26939887
http://dx.doi.org/10.1093/nar/gkw132

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