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New origin firing is inhibited by APC/C(Cdh1) activation in S-phase after severe replication stress
Defects in DNA replication and repair are known to promote genomic instability, a hallmark of cancer cells. Thus, eukaryotic cells have developed complex mechanisms to ensure accurate duplication of their genomes. While DNA damage response has been extensively studied in tumour cells, the pathways i...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889930/ https://www.ncbi.nlm.nih.gov/pubmed/26939887 http://dx.doi.org/10.1093/nar/gkw132 |