Insights into RNA binding by the anticancer drug cisplatin from the crystal structure of cisplatin-modified ribosome

Cisplatin is a widely prescribed anticancer drug, which triggers cell death by covalent binding to a broad range of biological molecules. Among cisplatin targets, cellular RNAs remain the most poorly characterized molecules. Although cisplatin was shown to inactivate essential RNAs, including riboso...

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Detalles Bibliográficos
Autores principales: Melnikov, Sergey V., Söll, Dieter, Steitz, Thomas A., Polikanov, Yury S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889946/
https://www.ncbi.nlm.nih.gov/pubmed/27079977
http://dx.doi.org/10.1093/nar/gkw246

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889946/
https://www.ncbi.nlm.nih.gov/pubmed/27079977
http://dx.doi.org/10.1093/nar/gkw246

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