Synergistic Effects of Gold Nanocages in Hyperthermia and Radiotherapy Treatment

Gold nanocages (GNCs) are a promising material that not only converts near infrared (NIR) light to heat for the ablation of tumors but also acts as a radiosensitizer. The combination of hyperthermia and radiotherapy has a synergistic effect that can lead to significant tumor cell necrosis. In the cu...

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Autores principales: Zhang, Ai-wei, Guo, Wei-hua, Qi, Ya-fei, Wang, Jian-zhen, Ma, Xiang-xing, Yu, De-xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2016
Materias:
Nano Express
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889960/
https://www.ncbi.nlm.nih.gov/pubmed/27255899
http://dx.doi.org/10.1186/s11671-016-1501-y
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author Zhang, Ai-wei
Guo, Wei-hua
Qi, Ya-fei
Wang, Jian-zhen
Ma, Xiang-xing
Yu, De-xin
author_facet Zhang, Ai-wei
Guo, Wei-hua
Qi, Ya-fei
Wang, Jian-zhen
Ma, Xiang-xing
Yu, De-xin
author_sort Zhang, Ai-wei
collection PubMed
description Gold nanocages (GNCs) are a promising material that not only converts near infrared (NIR) light to heat for the ablation of tumors but also acts as a radiosensitizer. The combination of hyperthermia and radiotherapy has a synergistic effect that can lead to significant tumor cell necrosis. In the current study, we synthesized GNCs that offered the combined effects of hyperthermia and radiotherapy. This combination strategy resulted in increased tumor cell apoptosis and significant tumor tissue necrosis. We propose that GNCs can be used for clinical treatment and to potentially overcome resistance to radiotherapy by clearly increasing the antitumor effect.
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spelling pubmed-48899602016-06-17 Synergistic Effects of Gold Nanocages in Hyperthermia and Radiotherapy Treatment Zhang, Ai-wei Guo, Wei-hua Qi, Ya-fei Wang, Jian-zhen Ma, Xiang-xing Yu, De-xin Nanoscale Res Lett Nano Express Gold nanocages (GNCs) are a promising material that not only converts near infrared (NIR) light to heat for the ablation of tumors but also acts as a radiosensitizer. The combination of hyperthermia and radiotherapy has a synergistic effect that can lead to significant tumor cell necrosis. In the current study, we synthesized GNCs that offered the combined effects of hyperthermia and radiotherapy. This combination strategy resulted in increased tumor cell apoptosis and significant tumor tissue necrosis. We propose that GNCs can be used for clinical treatment and to potentially overcome resistance to radiotherapy by clearly increasing the antitumor effect. Springer US 2016-06-02 /pmc/articles/PMC4889960/ /pubmed/27255899 http://dx.doi.org/10.1186/s11671-016-1501-y Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Nano Express
Zhang, Ai-wei
Guo, Wei-hua
Qi, Ya-fei
Wang, Jian-zhen
Ma, Xiang-xing
Yu, De-xin
Synergistic Effects of Gold Nanocages in Hyperthermia and Radiotherapy Treatment
title Synergistic Effects of Gold Nanocages in Hyperthermia and Radiotherapy Treatment
title_full Synergistic Effects of Gold Nanocages in Hyperthermia and Radiotherapy Treatment
title_fullStr Synergistic Effects of Gold Nanocages in Hyperthermia and Radiotherapy Treatment
title_full_unstemmed Synergistic Effects of Gold Nanocages in Hyperthermia and Radiotherapy Treatment
title_short Synergistic Effects of Gold Nanocages in Hyperthermia and Radiotherapy Treatment
title_sort synergistic effects of gold nanocages in hyperthermia and radiotherapy treatment
topic Nano Express
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889960/
https://www.ncbi.nlm.nih.gov/pubmed/27255899
http://dx.doi.org/10.1186/s11671-016-1501-y
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AT wangjianzhen synergisticeffectsofgoldnanocagesinhyperthermiaandradiotherapytreatment
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