Three-dimensional disorganization of the cancer genome occurs coincident with long-range genetic and epigenetic alterations

A three-dimensional chromatin state underpins the structural and functional basis of the genome by bringing regulatory elements and genes into close spatial proximity to ensure proper, cell-type–specific gene expression profiles. Here, we performed Hi-C chromosome conformation capture sequencing to...

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Detalles Bibliográficos
Autores principales: Taberlay, Phillippa C., Achinger-Kawecka, Joanna, Lun, Aaron T.L., Buske, Fabian A., Sabir, Kenneth, Gould, Cathryn M., Zotenko, Elena, Bert, Saul A., Giles, Katherine A., Bauer, Denis C., Smyth, Gordon K., Stirzaker, Clare, O'Donoghue, Sean I., Clark, Susan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889976/
https://www.ncbi.nlm.nih.gov/pubmed/27053337
http://dx.doi.org/10.1101/gr.201517.115

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