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Panacea seed “Nigella”: A review focusing on regenerative effects for gastric ailments

Nigella sativa (NS) or black cumin is a dark, thin, and crescent-shaped, seeded shrub belonging to the Ranunculaceae family commonly growing on Mediterranean coasts in Saudi Arabia, northern Africa and Asia. They have amazing curative and therapeutic features that make them one of the most popular,...

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Autores principales: Khan, Shahida A., Khan, Aziz M., Karim, Sajjad, Kamal, Mohammad Amjad, Damanhouri, Ghazi A., Mirza, Zeenat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890198/
https://www.ncbi.nlm.nih.gov/pubmed/27298589
http://dx.doi.org/10.1016/j.sjbs.2014.10.001
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author Khan, Shahida A.
Khan, Aziz M.
Karim, Sajjad
Kamal, Mohammad Amjad
Damanhouri, Ghazi A.
Mirza, Zeenat
author_facet Khan, Shahida A.
Khan, Aziz M.
Karim, Sajjad
Kamal, Mohammad Amjad
Damanhouri, Ghazi A.
Mirza, Zeenat
author_sort Khan, Shahida A.
collection PubMed
description Nigella sativa (NS) or black cumin is a dark, thin, and crescent-shaped, seeded shrub belonging to the Ranunculaceae family commonly growing on Mediterranean coasts in Saudi Arabia, northern Africa and Asia. They have amazing curative and therapeutic features that make them one of the most popular, safe, non-detrimental, and cytoprotective medicinal plant that can be used for prevention and treatment of many complicated diseases. Originally, N. sativa was used to treat migraines and allergy, and researches have shown its effectiveness in destroying cancer cells as well. The gastro protective effect of NS oil and its constituents has also been reported earlier; however, the complete perception on etiology and pathogenesis of gastric ulcer is not yet clear. Herein, we attempt to unveil some of the potential mechanisms exhibited by NS in preventing problems related to gastric ulcers. Gastric ailments like ulcers and tumors are the most common disorders of the gastro-intestinal tract in the present day life of the industrialized world. Gastric ulcer being a multifaceted problem exhibits complex etiology and is the fourth most common cause of cancer mortality. Drug interactions and toxicity are the main hindrances in chemotherapy. The existing merits and demerits of modern-day drugs make us turn toward the plant kingdom which may provide a valuable resource of novel potent natural compounds for pharmaceuticals or alternately, as dietary supplements. In this context, the revered phytotherapeutic N. sativa comes as a promising savior in today’s times. This review aims to summarize, both the functional and disease-related effects in the area of gastroenterology.
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spelling pubmed-48901982016-06-13 Panacea seed “Nigella”: A review focusing on regenerative effects for gastric ailments Khan, Shahida A. Khan, Aziz M. Karim, Sajjad Kamal, Mohammad Amjad Damanhouri, Ghazi A. Mirza, Zeenat Saudi J Biol Sci Original Article Nigella sativa (NS) or black cumin is a dark, thin, and crescent-shaped, seeded shrub belonging to the Ranunculaceae family commonly growing on Mediterranean coasts in Saudi Arabia, northern Africa and Asia. They have amazing curative and therapeutic features that make them one of the most popular, safe, non-detrimental, and cytoprotective medicinal plant that can be used for prevention and treatment of many complicated diseases. Originally, N. sativa was used to treat migraines and allergy, and researches have shown its effectiveness in destroying cancer cells as well. The gastro protective effect of NS oil and its constituents has also been reported earlier; however, the complete perception on etiology and pathogenesis of gastric ulcer is not yet clear. Herein, we attempt to unveil some of the potential mechanisms exhibited by NS in preventing problems related to gastric ulcers. Gastric ailments like ulcers and tumors are the most common disorders of the gastro-intestinal tract in the present day life of the industrialized world. Gastric ulcer being a multifaceted problem exhibits complex etiology and is the fourth most common cause of cancer mortality. Drug interactions and toxicity are the main hindrances in chemotherapy. The existing merits and demerits of modern-day drugs make us turn toward the plant kingdom which may provide a valuable resource of novel potent natural compounds for pharmaceuticals or alternately, as dietary supplements. In this context, the revered phytotherapeutic N. sativa comes as a promising savior in today’s times. This review aims to summarize, both the functional and disease-related effects in the area of gastroenterology. Elsevier 2016-07 2014-10-13 /pmc/articles/PMC4890198/ /pubmed/27298589 http://dx.doi.org/10.1016/j.sjbs.2014.10.001 Text en © 2014 The Authors http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Original Article
Khan, Shahida A.
Khan, Aziz M.
Karim, Sajjad
Kamal, Mohammad Amjad
Damanhouri, Ghazi A.
Mirza, Zeenat
Panacea seed “Nigella”: A review focusing on regenerative effects for gastric ailments
title Panacea seed “Nigella”: A review focusing on regenerative effects for gastric ailments
title_full Panacea seed “Nigella”: A review focusing on regenerative effects for gastric ailments
title_fullStr Panacea seed “Nigella”: A review focusing on regenerative effects for gastric ailments
title_full_unstemmed Panacea seed “Nigella”: A review focusing on regenerative effects for gastric ailments
title_short Panacea seed “Nigella”: A review focusing on regenerative effects for gastric ailments
title_sort panacea seed “nigella”: a review focusing on regenerative effects for gastric ailments
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890198/
https://www.ncbi.nlm.nih.gov/pubmed/27298589
http://dx.doi.org/10.1016/j.sjbs.2014.10.001
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