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Four-week rapamycin treatment improves muscular dystrophy in a fukutin-deficient mouse model of dystroglycanopathy

BACKGROUND: Secondary dystroglycanopathies are a subset of muscular dystrophy caused by abnormal glycosylation of α-dystroglycan (αDG). Loss of αDG functional glycosylation prevents it from binding to laminin and other extracellular matrix receptors, causing muscular dystrophy. Mutations in a number...

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Detalles Bibliográficos
Autores principales:	Foltz, Steven J., Luan, Junna, Call, Jarrod A., Patel, Ankit, Peissig, Kristen B., Fortunato, Marisa J., Beedle, Aaron M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890530/ https://www.ncbi.nlm.nih.gov/pubmed/27257474 http://dx.doi.org/10.1186/s13395-016-0091-9

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