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A role for PDGF-C/PDGFRα signaling in the formation of the meningeal basement membranes surrounding the cerebral cortex

Platelet-derived growth factor-C (PDGF-C) is one of three known ligands for the tyrosine kinase receptor PDGFRα. Analysis of Pdgfc null mice has demonstrated roles for PDGF-C in palate closure and the formation of cerebral ventricles, but redundancy with other PDGFRα ligands might obscure additional...

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Autores principales: Andrae, Johanna, Gouveia, Leonor, Gallini, Radiosa, He, Liqun, Fredriksson, Linda, Nilsson, Ingrid, Johansson, Bengt R., Eriksson, Ulf, Betsholtz, Christer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890675/
https://www.ncbi.nlm.nih.gov/pubmed/26988758
http://dx.doi.org/10.1242/bio.017368
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author Andrae, Johanna
Gouveia, Leonor
Gallini, Radiosa
He, Liqun
Fredriksson, Linda
Nilsson, Ingrid
Johansson, Bengt R.
Eriksson, Ulf
Betsholtz, Christer
author_facet Andrae, Johanna
Gouveia, Leonor
Gallini, Radiosa
He, Liqun
Fredriksson, Linda
Nilsson, Ingrid
Johansson, Bengt R.
Eriksson, Ulf
Betsholtz, Christer
author_sort Andrae, Johanna
collection PubMed
description Platelet-derived growth factor-C (PDGF-C) is one of three known ligands for the tyrosine kinase receptor PDGFRα. Analysis of Pdgfc null mice has demonstrated roles for PDGF-C in palate closure and the formation of cerebral ventricles, but redundancy with other PDGFRα ligands might obscure additional functions. In search of further developmental roles for PDGF-C, we generated mice that were double mutants for Pdgfc(−/−) and Pdgfra(GFP/+). These mice display a range of severe phenotypes including spina bifida, lung emphysema, abnormal meninges and neuronal over-migration in the cerebral cortex. We focused our analysis on the central nervous system (CNS), where PDGF-C was identified as a critical factor for the formation of meninges and assembly of the glia limitans basement membrane. We also present expression data on Pdgfa, Pdgfc and Pdgfra in the cerebral cortex and microarray data on cerebral meninges.
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spelling pubmed-48906752016-06-03 A role for PDGF-C/PDGFRα signaling in the formation of the meningeal basement membranes surrounding the cerebral cortex Andrae, Johanna Gouveia, Leonor Gallini, Radiosa He, Liqun Fredriksson, Linda Nilsson, Ingrid Johansson, Bengt R. Eriksson, Ulf Betsholtz, Christer Biol Open Research Article Platelet-derived growth factor-C (PDGF-C) is one of three known ligands for the tyrosine kinase receptor PDGFRα. Analysis of Pdgfc null mice has demonstrated roles for PDGF-C in palate closure and the formation of cerebral ventricles, but redundancy with other PDGFRα ligands might obscure additional functions. In search of further developmental roles for PDGF-C, we generated mice that were double mutants for Pdgfc(−/−) and Pdgfra(GFP/+). These mice display a range of severe phenotypes including spina bifida, lung emphysema, abnormal meninges and neuronal over-migration in the cerebral cortex. We focused our analysis on the central nervous system (CNS), where PDGF-C was identified as a critical factor for the formation of meninges and assembly of the glia limitans basement membrane. We also present expression data on Pdgfa, Pdgfc and Pdgfra in the cerebral cortex and microarray data on cerebral meninges. The Company of Biologists Ltd 2016-03-17 /pmc/articles/PMC4890675/ /pubmed/26988758 http://dx.doi.org/10.1242/bio.017368 Text en © 2016. Published by The Company of Biologists Ltd http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Research Article
Andrae, Johanna
Gouveia, Leonor
Gallini, Radiosa
He, Liqun
Fredriksson, Linda
Nilsson, Ingrid
Johansson, Bengt R.
Eriksson, Ulf
Betsholtz, Christer
A role for PDGF-C/PDGFRα signaling in the formation of the meningeal basement membranes surrounding the cerebral cortex
title A role for PDGF-C/PDGFRα signaling in the formation of the meningeal basement membranes surrounding the cerebral cortex
title_full A role for PDGF-C/PDGFRα signaling in the formation of the meningeal basement membranes surrounding the cerebral cortex
title_fullStr A role for PDGF-C/PDGFRα signaling in the formation of the meningeal basement membranes surrounding the cerebral cortex
title_full_unstemmed A role for PDGF-C/PDGFRα signaling in the formation of the meningeal basement membranes surrounding the cerebral cortex
title_short A role for PDGF-C/PDGFRα signaling in the formation of the meningeal basement membranes surrounding the cerebral cortex
title_sort role for pdgf-c/pdgfrα signaling in the formation of the meningeal basement membranes surrounding the cerebral cortex
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890675/
https://www.ncbi.nlm.nih.gov/pubmed/26988758
http://dx.doi.org/10.1242/bio.017368
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