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The cellular composition of the human immune system is shaped by age and cohabitation

Detailed population-level description of the human immune system has recently become achievable. We used a “systems-level” approach to establish a resource of cellular immune profiles of 670 healthy individuals. We report a high level of inter-individual variation, with low longitudinal variation, a...

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Autores principales: Carr, Edward J., Dooley, James, Garcia-Perez, Josselyn E., Lagou, Vasiliki, Lee, James C., Wouters, Carine, Meyts, Isabelle, Goris, An, Boeckxstaens, Guy, Linterman, Michelle A., Liston, Adrian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890679/
https://www.ncbi.nlm.nih.gov/pubmed/26878114
http://dx.doi.org/10.1038/ni.3371
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author Carr, Edward J.
Dooley, James
Garcia-Perez, Josselyn E.
Lagou, Vasiliki
Lee, James C.
Wouters, Carine
Meyts, Isabelle
Goris, An
Boeckxstaens, Guy
Linterman, Michelle A.
Liston, Adrian
author_facet Carr, Edward J.
Dooley, James
Garcia-Perez, Josselyn E.
Lagou, Vasiliki
Lee, James C.
Wouters, Carine
Meyts, Isabelle
Goris, An
Boeckxstaens, Guy
Linterman, Michelle A.
Liston, Adrian
author_sort Carr, Edward J.
collection PubMed
description Detailed population-level description of the human immune system has recently become achievable. We used a “systems-level” approach to establish a resource of cellular immune profiles of 670 healthy individuals. We report a high level of inter-individual variation, with low longitudinal variation, at the level of cellular subset composition of the immune system. Despite the profound effects of antigen exposure on individual antigen-specific clones, the cellular subset structure proved highly elastic, with transient vaccination-induced changes being followed by a return to the unique baseline of the individual. Strikingly, the largest influence on immunological variation identified was cohabitation, with a 50% reduction in immunological variation between individuals who share an environment (parents) compared to the wider population. These results identify local environmental conditions are a key shaper of the human immune system.
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spelling pubmed-48906792016-09-22 The cellular composition of the human immune system is shaped by age and cohabitation Carr, Edward J. Dooley, James Garcia-Perez, Josselyn E. Lagou, Vasiliki Lee, James C. Wouters, Carine Meyts, Isabelle Goris, An Boeckxstaens, Guy Linterman, Michelle A. Liston, Adrian Nat Immunol Article Detailed population-level description of the human immune system has recently become achievable. We used a “systems-level” approach to establish a resource of cellular immune profiles of 670 healthy individuals. We report a high level of inter-individual variation, with low longitudinal variation, at the level of cellular subset composition of the immune system. Despite the profound effects of antigen exposure on individual antigen-specific clones, the cellular subset structure proved highly elastic, with transient vaccination-induced changes being followed by a return to the unique baseline of the individual. Strikingly, the largest influence on immunological variation identified was cohabitation, with a 50% reduction in immunological variation between individuals who share an environment (parents) compared to the wider population. These results identify local environmental conditions are a key shaper of the human immune system. 2016-04-01 2016-02-15 /pmc/articles/PMC4890679/ /pubmed/26878114 http://dx.doi.org/10.1038/ni.3371 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Carr, Edward J.
Dooley, James
Garcia-Perez, Josselyn E.
Lagou, Vasiliki
Lee, James C.
Wouters, Carine
Meyts, Isabelle
Goris, An
Boeckxstaens, Guy
Linterman, Michelle A.
Liston, Adrian
The cellular composition of the human immune system is shaped by age and cohabitation
title The cellular composition of the human immune system is shaped by age and cohabitation
title_full The cellular composition of the human immune system is shaped by age and cohabitation
title_fullStr The cellular composition of the human immune system is shaped by age and cohabitation
title_full_unstemmed The cellular composition of the human immune system is shaped by age and cohabitation
title_short The cellular composition of the human immune system is shaped by age and cohabitation
title_sort cellular composition of the human immune system is shaped by age and cohabitation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890679/
https://www.ncbi.nlm.nih.gov/pubmed/26878114
http://dx.doi.org/10.1038/ni.3371
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