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The arsenal of pathogens and antivirulence therapeutic strategies for disarming them

Pathogens deploy an arsenal of virulence factors (VFs) to establish themselves within their infectious niche. The discovery of antimicrobial compounds and their development into therapeutics has made a monumental impact on human and microbial populations. Although humans have used antimicrobials for...

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Autores principales: Brannon, John R, Hadjifrangiskou, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890686/
https://www.ncbi.nlm.nih.gov/pubmed/27313446
http://dx.doi.org/10.2147/DDDT.S98939
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author Brannon, John R
Hadjifrangiskou, Maria
author_facet Brannon, John R
Hadjifrangiskou, Maria
author_sort Brannon, John R
collection PubMed
description Pathogens deploy an arsenal of virulence factors (VFs) to establish themselves within their infectious niche. The discovery of antimicrobial compounds and their development into therapeutics has made a monumental impact on human and microbial populations. Although humans have used antimicrobials for medicinal and agricultural purposes, microorganism populations have developed and shared resistance mechanisms to persevere in the face of classical antimicrobials. However, a positive substitute is antivirulence therapy; antivirulence therapeutics prevent or interrupt an infection by counteracting a pathogen’s VFs. Their application can reduce the use of broad-spectrum antimicrobials and dampen the frequency with which resistant strains emerge. Here, we summarize the contribution of VFs to various acute and chronic infections. In correspondence with this, we provide an overview of the research and development of antivirulence strategies.
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spelling pubmed-48906862016-06-16 The arsenal of pathogens and antivirulence therapeutic strategies for disarming them Brannon, John R Hadjifrangiskou, Maria Drug Des Devel Ther Review Pathogens deploy an arsenal of virulence factors (VFs) to establish themselves within their infectious niche. The discovery of antimicrobial compounds and their development into therapeutics has made a monumental impact on human and microbial populations. Although humans have used antimicrobials for medicinal and agricultural purposes, microorganism populations have developed and shared resistance mechanisms to persevere in the face of classical antimicrobials. However, a positive substitute is antivirulence therapy; antivirulence therapeutics prevent or interrupt an infection by counteracting a pathogen’s VFs. Their application can reduce the use of broad-spectrum antimicrobials and dampen the frequency with which resistant strains emerge. Here, we summarize the contribution of VFs to various acute and chronic infections. In correspondence with this, we provide an overview of the research and development of antivirulence strategies. Dove Medical Press 2016-05-27 /pmc/articles/PMC4890686/ /pubmed/27313446 http://dx.doi.org/10.2147/DDDT.S98939 Text en © 2016 Brannon and Hadjifrangiskou. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Brannon, John R
Hadjifrangiskou, Maria
The arsenal of pathogens and antivirulence therapeutic strategies for disarming them
title The arsenal of pathogens and antivirulence therapeutic strategies for disarming them
title_full The arsenal of pathogens and antivirulence therapeutic strategies for disarming them
title_fullStr The arsenal of pathogens and antivirulence therapeutic strategies for disarming them
title_full_unstemmed The arsenal of pathogens and antivirulence therapeutic strategies for disarming them
title_short The arsenal of pathogens and antivirulence therapeutic strategies for disarming them
title_sort arsenal of pathogens and antivirulence therapeutic strategies for disarming them
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890686/
https://www.ncbi.nlm.nih.gov/pubmed/27313446
http://dx.doi.org/10.2147/DDDT.S98939
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