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Predicting Allosteric Effects from Orthosteric Binding in Hsp90-Ligand Interactions: Implications for Fragment-Based Drug Design

A key question in mapping dynamics of protein-ligand interactions is to distinguish changes at binding sites from those associated with long range conformational changes upon binding at distal sites. This assumes a greater challenge when considering the interactions of low affinity ligands (dissocia...

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Detalles Bibliográficos
Autores principales:	Chandramohan, Arun, Krishnamurthy, Srinath, Larsson, Andreas, Nordlund, Paer, Jansson, Anna, Anand, Ganesh S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890749/ https://www.ncbi.nlm.nih.gov/pubmed/27253209 http://dx.doi.org/10.1371/journal.pcbi.1004840

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