Depletion of Histone Demethylase Jarid1A Resulting in Histone Hyperacetylation and Radiation Sensitivity Does Not Affect DNA Double-Strand Break Repair

Histone demethylases have recently gained interest as potential targets in cancer treatment and several histone demethylases have been implicated in the DNA damage response. We investigated the effects of siRNA-mediated depletion of histone demethylase Jarid1A (KDM5A, RBP2), which demethylates trans...

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Detalles Bibliográficos
Autores principales: Penterling, Corina, Drexler, Guido A., Böhland, Claudia, Stamp, Ramona, Wilke, Christina, Braselmann, Herbert, Caldwell, Randolph B., Reindl, Judith, Girst, Stefanie, Greubel, Christoph, Siebenwirth, Christian, Mansour, Wael Y., Borgmann, Kerstin, Dollinger, Günther, Unger, Kristian, Friedl, Anna A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890786/
https://www.ncbi.nlm.nih.gov/pubmed/27253695
http://dx.doi.org/10.1371/journal.pone.0156599

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