Modeling and Re-Engineering of Azotobacter vinelandii Alginate Lyase to Enhance Its Catalytic Efficiency for Accelerating Biofilm Degradation

Alginate is known to prevent elimination of Pseudomonas aeruginosa biofilms. Alginate lyase (AlgL) might therefore facilitate treatment of Pseudomonas aeruginosa-infected cystic fibrosis patients. However, the catalytic activity of wild-type AlgL is not sufficiently high. Therefore, molecular modeli...

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Detalles Bibliográficos
Autores principales: Jang, Chul Ho, Piao, Yu Lan, Huang, Xiaoqin, Yoon, Eun Jeong, Park, So Hee, Lee, Kyoung, Zhan, Chang-Guo, Cho, Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890793/
https://www.ncbi.nlm.nih.gov/pubmed/27253324
http://dx.doi.org/10.1371/journal.pone.0156197

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890793/
https://www.ncbi.nlm.nih.gov/pubmed/27253324
http://dx.doi.org/10.1371/journal.pone.0156197

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