Cognitive Impairments Induced by Concussive Mild Traumatic Brain Injury in Mouse Are Ameliorated by Treatment with Phenserine via Multiple Non-Cholinergic and Cholinergic Mechanisms

Traumatic brain injury (TBI), often caused by a concussive impact to the head, affects an estimated 1.7 million Americans annually. With no approved drugs, its pharmacological treatment represents a significant and currently unmet medical need. In our prior development of the anti-cholinesterase com...

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Detalles Bibliográficos
Autores principales: Tweedie, David, Fukui, Koji, Li, Yazhou, Yu, Qian-sheng, Barak, Shani, Tamargo, Ian A., Rubovitch, Vardit, Holloway, Harold W., Lehrmann, Elin, Wood, William H., Zhang, Yongqing, Becker, Kevin G., Perez, Evelyn, Van Praag, Henriette, Luo, Yu, Hoffer, Barry J., Becker, Robert E., Pick, Chaim G., Greig, Nigel H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890804/
https://www.ncbi.nlm.nih.gov/pubmed/27254111
http://dx.doi.org/10.1371/journal.pone.0156493

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