PIMASERTIB AND SEROUS RETINAL DETACHMENTS

PURPOSE: To report a case of multifocal serous retinal detachments associated with pimasertib. METHODS: The authors report a 26-year-old patient who developed bilateral multifocal serous retinal detachments appearing 2 days after starting pimasertib (as part of a clinical trial investigating its use...

Descripción completa

Detalles Bibliográficos
Autores principales: AlAli, Alaa, Bushehri, Ahmad, Park, Jonathan C., Krema, Hatem, Lam, Wai-Ching
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Retinal Cases & Brief Reports 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890820/
https://www.ncbi.nlm.nih.gov/pubmed/26444523
http://dx.doi.org/10.1097/ICB.0000000000000228
_version_ 1782435162771947520
author AlAli, Alaa
Bushehri, Ahmad
Park, Jonathan C.
Krema, Hatem
Lam, Wai-Ching
author_facet AlAli, Alaa
Bushehri, Ahmad
Park, Jonathan C.
Krema, Hatem
Lam, Wai-Ching
author_sort AlAli, Alaa
collection PubMed
description PURPOSE: To report a case of multifocal serous retinal detachments associated with pimasertib. METHODS: The authors report a 26-year-old patient who developed bilateral multifocal serous retinal detachments appearing 2 days after starting pimasertib (as part of a clinical trial investigating its use in low-grade metastatic ovarian cancer) and rapidly resolving 3 days after stopping it. CONCLUSION: The mechanism of MEK inhibitor induced visual toxicity remains unclear. The pathophysiology of multifocal serous retinal detachments as a complication of pimasertib is still poorly understood.
format Online
Article
Text
id pubmed-4890820
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Retinal Cases & Brief Reports
record_format MEDLINE/PubMed
spelling pubmed-48908202016-06-21 PIMASERTIB AND SEROUS RETINAL DETACHMENTS AlAli, Alaa Bushehri, Ahmad Park, Jonathan C. Krema, Hatem Lam, Wai-Ching Retin Cases Brief Rep Case Report PURPOSE: To report a case of multifocal serous retinal detachments associated with pimasertib. METHODS: The authors report a 26-year-old patient who developed bilateral multifocal serous retinal detachments appearing 2 days after starting pimasertib (as part of a clinical trial investigating its use in low-grade metastatic ovarian cancer) and rapidly resolving 3 days after stopping it. CONCLUSION: The mechanism of MEK inhibitor induced visual toxicity remains unclear. The pathophysiology of multifocal serous retinal detachments as a complication of pimasertib is still poorly understood. Retinal Cases & Brief Reports 2016 2016-04-04 /pmc/articles/PMC4890820/ /pubmed/26444523 http://dx.doi.org/10.1097/ICB.0000000000000228 Text en This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially.
spellingShingle Case Report
AlAli, Alaa
Bushehri, Ahmad
Park, Jonathan C.
Krema, Hatem
Lam, Wai-Ching
PIMASERTIB AND SEROUS RETINAL DETACHMENTS
title PIMASERTIB AND SEROUS RETINAL DETACHMENTS
title_full PIMASERTIB AND SEROUS RETINAL DETACHMENTS
title_fullStr PIMASERTIB AND SEROUS RETINAL DETACHMENTS
title_full_unstemmed PIMASERTIB AND SEROUS RETINAL DETACHMENTS
title_short PIMASERTIB AND SEROUS RETINAL DETACHMENTS
title_sort pimasertib and serous retinal detachments
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890820/
https://www.ncbi.nlm.nih.gov/pubmed/26444523
http://dx.doi.org/10.1097/ICB.0000000000000228
work_keys_str_mv AT alalialaa pimasertibandserousretinaldetachments
AT bushehriahmad pimasertibandserousretinaldetachments
AT parkjonathanc pimasertibandserousretinaldetachments
AT kremahatem pimasertibandserousretinaldetachments
AT lamwaiching pimasertibandserousretinaldetachments

Ejemplares similares