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NT-proBNP Changes in Patients with Ascites during Large Volume Paracentesis

Background. N-terminal probrain natriuretic peptide (NT-proBNP) is a hormone involved in the regulation of cardiovascular homeostasis. Changes in serum NT-proBNP during large volume paracentesis (LVP) in patients with ascites have never before been examined. Aims. To determine if significant changes...

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Autores principales: Nguyen, Vi, Zielinski, Rob, Harnett, Paul, Miller, Katherine, Chan, Henry, Vootakuru, Nikitha, Acharya, Priya, Khan, Montaha, Gibbs, Oliver, Gupta, Sarika, Devi, Anjla, Phillips, Shani, George, Jacob, van der Poorten, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890870/
https://www.ncbi.nlm.nih.gov/pubmed/27335835
http://dx.doi.org/10.1155/2013/959474
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author Nguyen, Vi
Zielinski, Rob
Harnett, Paul
Miller, Katherine
Chan, Henry
Vootakuru, Nikitha
Acharya, Priya
Khan, Montaha
Gibbs, Oliver
Gupta, Sarika
Devi, Anjla
Phillips, Shani
George, Jacob
van der Poorten, David
author_facet Nguyen, Vi
Zielinski, Rob
Harnett, Paul
Miller, Katherine
Chan, Henry
Vootakuru, Nikitha
Acharya, Priya
Khan, Montaha
Gibbs, Oliver
Gupta, Sarika
Devi, Anjla
Phillips, Shani
George, Jacob
van der Poorten, David
author_sort Nguyen, Vi
collection PubMed
description Background. N-terminal probrain natriuretic peptide (NT-proBNP) is a hormone involved in the regulation of cardiovascular homeostasis. Changes in serum NT-proBNP during large volume paracentesis (LVP) in patients with ascites have never before been examined. Aims. To determine if significant changes in serum NT-proBNP occur in patients undergoing LVP and the associated clinical correlates in patients with cirrhosis. Method. A total of 45 patients with ascites were prospectively recruited. Serum NT-proBNP, biochemistry, and haemodynamics were determined at baseline and at key time points during and after paracentesis. Results. 34 patients were analysed; 19 had ascites due to cirrhosis and 15 from malignancy. In those with cirrhosis, NT-proBNP decreased by 77.3 pg/mL at 2 L of drainage and 94.3 pg/mL at the end of paracentesis, compared with an increase of 10.5 pg/mL and 77.2 pg/mL in cancer patients at the same time points (P = 0.05 and P = 0.03). Only congestive cardiac failure (CCF) was an independent predictor of significant NT-proBNP changes at the end of drainage in cirrhotic patients (P < 0.01). There were no significant changes in haemodynamics or renal biochemistry for either group. Conclusion. Significant reductions in serum NT-proBNP during LVP occur in patients with cirrhosis but not malignancy, and only comorbid CCF appeared to predict such changes.
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spelling pubmed-48908702016-06-22 NT-proBNP Changes in Patients with Ascites during Large Volume Paracentesis Nguyen, Vi Zielinski, Rob Harnett, Paul Miller, Katherine Chan, Henry Vootakuru, Nikitha Acharya, Priya Khan, Montaha Gibbs, Oliver Gupta, Sarika Devi, Anjla Phillips, Shani George, Jacob van der Poorten, David ISRN Hepatol Clinical Study Background. N-terminal probrain natriuretic peptide (NT-proBNP) is a hormone involved in the regulation of cardiovascular homeostasis. Changes in serum NT-proBNP during large volume paracentesis (LVP) in patients with ascites have never before been examined. Aims. To determine if significant changes in serum NT-proBNP occur in patients undergoing LVP and the associated clinical correlates in patients with cirrhosis. Method. A total of 45 patients with ascites were prospectively recruited. Serum NT-proBNP, biochemistry, and haemodynamics were determined at baseline and at key time points during and after paracentesis. Results. 34 patients were analysed; 19 had ascites due to cirrhosis and 15 from malignancy. In those with cirrhosis, NT-proBNP decreased by 77.3 pg/mL at 2 L of drainage and 94.3 pg/mL at the end of paracentesis, compared with an increase of 10.5 pg/mL and 77.2 pg/mL in cancer patients at the same time points (P = 0.05 and P = 0.03). Only congestive cardiac failure (CCF) was an independent predictor of significant NT-proBNP changes at the end of drainage in cirrhotic patients (P < 0.01). There were no significant changes in haemodynamics or renal biochemistry for either group. Conclusion. Significant reductions in serum NT-proBNP during LVP occur in patients with cirrhosis but not malignancy, and only comorbid CCF appeared to predict such changes. Hindawi Publishing Corporation 2013-09-22 /pmc/articles/PMC4890870/ /pubmed/27335835 http://dx.doi.org/10.1155/2013/959474 Text en Copyright © 2013 Vi Nguyen et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Nguyen, Vi
Zielinski, Rob
Harnett, Paul
Miller, Katherine
Chan, Henry
Vootakuru, Nikitha
Acharya, Priya
Khan, Montaha
Gibbs, Oliver
Gupta, Sarika
Devi, Anjla
Phillips, Shani
George, Jacob
van der Poorten, David
NT-proBNP Changes in Patients with Ascites during Large Volume Paracentesis
title NT-proBNP Changes in Patients with Ascites during Large Volume Paracentesis
title_full NT-proBNP Changes in Patients with Ascites during Large Volume Paracentesis
title_fullStr NT-proBNP Changes in Patients with Ascites during Large Volume Paracentesis
title_full_unstemmed NT-proBNP Changes in Patients with Ascites during Large Volume Paracentesis
title_short NT-proBNP Changes in Patients with Ascites during Large Volume Paracentesis
title_sort nt-probnp changes in patients with ascites during large volume paracentesis
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890870/
https://www.ncbi.nlm.nih.gov/pubmed/27335835
http://dx.doi.org/10.1155/2013/959474
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