Cargando…
NT-proBNP Changes in Patients with Ascites during Large Volume Paracentesis
Background. N-terminal probrain natriuretic peptide (NT-proBNP) is a hormone involved in the regulation of cardiovascular homeostasis. Changes in serum NT-proBNP during large volume paracentesis (LVP) in patients with ascites have never before been examined. Aims. To determine if significant changes...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890870/ https://www.ncbi.nlm.nih.gov/pubmed/27335835 http://dx.doi.org/10.1155/2013/959474 |
_version_ | 1782435173693915136 |
---|---|
author | Nguyen, Vi Zielinski, Rob Harnett, Paul Miller, Katherine Chan, Henry Vootakuru, Nikitha Acharya, Priya Khan, Montaha Gibbs, Oliver Gupta, Sarika Devi, Anjla Phillips, Shani George, Jacob van der Poorten, David |
author_facet | Nguyen, Vi Zielinski, Rob Harnett, Paul Miller, Katherine Chan, Henry Vootakuru, Nikitha Acharya, Priya Khan, Montaha Gibbs, Oliver Gupta, Sarika Devi, Anjla Phillips, Shani George, Jacob van der Poorten, David |
author_sort | Nguyen, Vi |
collection | PubMed |
description | Background. N-terminal probrain natriuretic peptide (NT-proBNP) is a hormone involved in the regulation of cardiovascular homeostasis. Changes in serum NT-proBNP during large volume paracentesis (LVP) in patients with ascites have never before been examined. Aims. To determine if significant changes in serum NT-proBNP occur in patients undergoing LVP and the associated clinical correlates in patients with cirrhosis. Method. A total of 45 patients with ascites were prospectively recruited. Serum NT-proBNP, biochemistry, and haemodynamics were determined at baseline and at key time points during and after paracentesis. Results. 34 patients were analysed; 19 had ascites due to cirrhosis and 15 from malignancy. In those with cirrhosis, NT-proBNP decreased by 77.3 pg/mL at 2 L of drainage and 94.3 pg/mL at the end of paracentesis, compared with an increase of 10.5 pg/mL and 77.2 pg/mL in cancer patients at the same time points (P = 0.05 and P = 0.03). Only congestive cardiac failure (CCF) was an independent predictor of significant NT-proBNP changes at the end of drainage in cirrhotic patients (P < 0.01). There were no significant changes in haemodynamics or renal biochemistry for either group. Conclusion. Significant reductions in serum NT-proBNP during LVP occur in patients with cirrhosis but not malignancy, and only comorbid CCF appeared to predict such changes. |
format | Online Article Text |
id | pubmed-4890870 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-48908702016-06-22 NT-proBNP Changes in Patients with Ascites during Large Volume Paracentesis Nguyen, Vi Zielinski, Rob Harnett, Paul Miller, Katherine Chan, Henry Vootakuru, Nikitha Acharya, Priya Khan, Montaha Gibbs, Oliver Gupta, Sarika Devi, Anjla Phillips, Shani George, Jacob van der Poorten, David ISRN Hepatol Clinical Study Background. N-terminal probrain natriuretic peptide (NT-proBNP) is a hormone involved in the regulation of cardiovascular homeostasis. Changes in serum NT-proBNP during large volume paracentesis (LVP) in patients with ascites have never before been examined. Aims. To determine if significant changes in serum NT-proBNP occur in patients undergoing LVP and the associated clinical correlates in patients with cirrhosis. Method. A total of 45 patients with ascites were prospectively recruited. Serum NT-proBNP, biochemistry, and haemodynamics were determined at baseline and at key time points during and after paracentesis. Results. 34 patients were analysed; 19 had ascites due to cirrhosis and 15 from malignancy. In those with cirrhosis, NT-proBNP decreased by 77.3 pg/mL at 2 L of drainage and 94.3 pg/mL at the end of paracentesis, compared with an increase of 10.5 pg/mL and 77.2 pg/mL in cancer patients at the same time points (P = 0.05 and P = 0.03). Only congestive cardiac failure (CCF) was an independent predictor of significant NT-proBNP changes at the end of drainage in cirrhotic patients (P < 0.01). There were no significant changes in haemodynamics or renal biochemistry for either group. Conclusion. Significant reductions in serum NT-proBNP during LVP occur in patients with cirrhosis but not malignancy, and only comorbid CCF appeared to predict such changes. Hindawi Publishing Corporation 2013-09-22 /pmc/articles/PMC4890870/ /pubmed/27335835 http://dx.doi.org/10.1155/2013/959474 Text en Copyright © 2013 Vi Nguyen et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Nguyen, Vi Zielinski, Rob Harnett, Paul Miller, Katherine Chan, Henry Vootakuru, Nikitha Acharya, Priya Khan, Montaha Gibbs, Oliver Gupta, Sarika Devi, Anjla Phillips, Shani George, Jacob van der Poorten, David NT-proBNP Changes in Patients with Ascites during Large Volume Paracentesis |
title | NT-proBNP Changes in Patients with Ascites during Large Volume Paracentesis |
title_full | NT-proBNP Changes in Patients with Ascites during Large Volume Paracentesis |
title_fullStr | NT-proBNP Changes in Patients with Ascites during Large Volume Paracentesis |
title_full_unstemmed | NT-proBNP Changes in Patients with Ascites during Large Volume Paracentesis |
title_short | NT-proBNP Changes in Patients with Ascites during Large Volume Paracentesis |
title_sort | nt-probnp changes in patients with ascites during large volume paracentesis |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890870/ https://www.ncbi.nlm.nih.gov/pubmed/27335835 http://dx.doi.org/10.1155/2013/959474 |
work_keys_str_mv | AT nguyenvi ntprobnpchangesinpatientswithascitesduringlargevolumeparacentesis AT zielinskirob ntprobnpchangesinpatientswithascitesduringlargevolumeparacentesis AT harnettpaul ntprobnpchangesinpatientswithascitesduringlargevolumeparacentesis AT millerkatherine ntprobnpchangesinpatientswithascitesduringlargevolumeparacentesis AT chanhenry ntprobnpchangesinpatientswithascitesduringlargevolumeparacentesis AT vootakurunikitha ntprobnpchangesinpatientswithascitesduringlargevolumeparacentesis AT acharyapriya ntprobnpchangesinpatientswithascitesduringlargevolumeparacentesis AT khanmontaha ntprobnpchangesinpatientswithascitesduringlargevolumeparacentesis AT gibbsoliver ntprobnpchangesinpatientswithascitesduringlargevolumeparacentesis AT guptasarika ntprobnpchangesinpatientswithascitesduringlargevolumeparacentesis AT devianjla ntprobnpchangesinpatientswithascitesduringlargevolumeparacentesis AT phillipsshani ntprobnpchangesinpatientswithascitesduringlargevolumeparacentesis AT georgejacob ntprobnpchangesinpatientswithascitesduringlargevolumeparacentesis AT vanderpoortendavid ntprobnpchangesinpatientswithascitesduringlargevolumeparacentesis |