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Adenovirus-mediated downregulation of the ubiquitin ligase RNF8 sensitizes bladder cancer to radiotherapy

The ubiquitin ligase RNF8 promotes the DNA damage response (DDR). We observed that the expression of RNF8 was increased in bladder cancer cells and that this change in RNF8 expression could be reversed by adenovirus-mediated shRNA treatment. Moreover, we found that RNF8 knockdown sensitized bladder...

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Detalles Bibliográficos
Autores principales:	Zhao, Mei-Jun, Song, Yan-Feng, Niu, Hai-Tao, Tian, Ying-Xia, Yang, Xu-Guang, Xie, Kun, Jing, Yu-Hong, Wang, De-Gui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891017/ https://www.ncbi.nlm.nih.gov/pubmed/26788910 http://dx.doi.org/10.18632/oncotarget.6909

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