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EGFR-activating mutations, DNA copy number abundance of ErbB family, and prognosis in lung adenocarcinoma
In this study, EGFR-activating mutation status and DNA copy number abundances of members of ErbB family were measured in 261 lung adenocarcinomas. The associations between DNA copy number abundances of ErbB family, EGFR-activating mutation status, and prognosis were explored. Results showed that DNA...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891022/ https://www.ncbi.nlm.nih.gov/pubmed/26824984 http://dx.doi.org/10.18632/oncotarget.7029 |
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author | Chen, Hsuan-Yu Liu, Chia-Hsin Chang, Ya-Hsuan Yu, Sung-Liang Ho, Bing-Ching Hsu, Chung-Ping Yang, Tsung-Ying Chen, Kun-Chieh Hsu, Kuo-Hsuan Tseng, Jeng-Sen Hsia, Jiun-Yi Chuang, Cheng-Yen Chang, Chi-Sheng Li, Yu-Cheng Li, Ker-Chau Chang, Gee-Chen Yang, Pan-Chyr |
author_facet | Chen, Hsuan-Yu Liu, Chia-Hsin Chang, Ya-Hsuan Yu, Sung-Liang Ho, Bing-Ching Hsu, Chung-Ping Yang, Tsung-Ying Chen, Kun-Chieh Hsu, Kuo-Hsuan Tseng, Jeng-Sen Hsia, Jiun-Yi Chuang, Cheng-Yen Chang, Chi-Sheng Li, Yu-Cheng Li, Ker-Chau Chang, Gee-Chen Yang, Pan-Chyr |
author_sort | Chen, Hsuan-Yu |
collection | PubMed |
description | In this study, EGFR-activating mutation status and DNA copy number abundances of members of ErbB family were measured in 261 lung adenocarcinomas. The associations between DNA copy number abundances of ErbB family, EGFR-activating mutation status, and prognosis were explored. Results showed that DNA copy number abundances of EGFR, ERBB2, ERBB3, and ERBB4 had associations with overall survival in lung adenocarcinoma with EGFR-activating mutations. In the stratification analysis, only ERBB2 showed significant discrepancy in patients carrying wild type EGFR and other members of ErbB family in patients carrying EGFR-activating mutation. This indicated that CNAs of ErbB family had effect modifications of EGFR-activating mutation status. Findings of this study demonstrate potential molecular guidance of patient management of lung adenocarcinoma with or without EGFR-activating mutations. |
format | Online Article Text |
id | pubmed-4891022 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-48910222016-06-20 EGFR-activating mutations, DNA copy number abundance of ErbB family, and prognosis in lung adenocarcinoma Chen, Hsuan-Yu Liu, Chia-Hsin Chang, Ya-Hsuan Yu, Sung-Liang Ho, Bing-Ching Hsu, Chung-Ping Yang, Tsung-Ying Chen, Kun-Chieh Hsu, Kuo-Hsuan Tseng, Jeng-Sen Hsia, Jiun-Yi Chuang, Cheng-Yen Chang, Chi-Sheng Li, Yu-Cheng Li, Ker-Chau Chang, Gee-Chen Yang, Pan-Chyr Oncotarget Research Paper In this study, EGFR-activating mutation status and DNA copy number abundances of members of ErbB family were measured in 261 lung adenocarcinomas. The associations between DNA copy number abundances of ErbB family, EGFR-activating mutation status, and prognosis were explored. Results showed that DNA copy number abundances of EGFR, ERBB2, ERBB3, and ERBB4 had associations with overall survival in lung adenocarcinoma with EGFR-activating mutations. In the stratification analysis, only ERBB2 showed significant discrepancy in patients carrying wild type EGFR and other members of ErbB family in patients carrying EGFR-activating mutation. This indicated that CNAs of ErbB family had effect modifications of EGFR-activating mutation status. Findings of this study demonstrate potential molecular guidance of patient management of lung adenocarcinoma with or without EGFR-activating mutations. Impact Journals LLC 2016-01-27 /pmc/articles/PMC4891022/ /pubmed/26824984 http://dx.doi.org/10.18632/oncotarget.7029 Text en Copyright: © 2016 Chen et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Chen, Hsuan-Yu Liu, Chia-Hsin Chang, Ya-Hsuan Yu, Sung-Liang Ho, Bing-Ching Hsu, Chung-Ping Yang, Tsung-Ying Chen, Kun-Chieh Hsu, Kuo-Hsuan Tseng, Jeng-Sen Hsia, Jiun-Yi Chuang, Cheng-Yen Chang, Chi-Sheng Li, Yu-Cheng Li, Ker-Chau Chang, Gee-Chen Yang, Pan-Chyr EGFR-activating mutations, DNA copy number abundance of ErbB family, and prognosis in lung adenocarcinoma |
title | EGFR-activating mutations, DNA copy number abundance of ErbB family, and prognosis in lung adenocarcinoma |
title_full | EGFR-activating mutations, DNA copy number abundance of ErbB family, and prognosis in lung adenocarcinoma |
title_fullStr | EGFR-activating mutations, DNA copy number abundance of ErbB family, and prognosis in lung adenocarcinoma |
title_full_unstemmed | EGFR-activating mutations, DNA copy number abundance of ErbB family, and prognosis in lung adenocarcinoma |
title_short | EGFR-activating mutations, DNA copy number abundance of ErbB family, and prognosis in lung adenocarcinoma |
title_sort | egfr-activating mutations, dna copy number abundance of erbb family, and prognosis in lung adenocarcinoma |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891022/ https://www.ncbi.nlm.nih.gov/pubmed/26824984 http://dx.doi.org/10.18632/oncotarget.7029 |
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