A novel small molecule agent displays potent anti-myeloma activity by inhibiting the JAK2-STAT3 signaling pathway

The oncogenic STAT3 signaling pathway is emerging as a promising target for the treatment of multiple myeloma (MM). In the present study, we identified a novel STAT3 inhibitor SC99 in a target-based high throughput screen. SC99 inhibited JAK2-STAT3 activation but had no effects on other transcriptio...

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Detalles Bibliográficos
Autores principales: Zhang, Zubin, Mao, Hongwu, Du, Xiaolin, Zhu, Jingyu, Xu, Yujia, Wang, Siyu, Xu, Xin, Ji, Peng, Yu, Yang, Cao, Biyin, Han, Kunkun, Hou, Tingjun, Xu, Zhuan, Kong, Yan, Jiang, Gaofeng, Tang, Xiaowen, Qiao, Chunhua, Mao, Xinliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891041/
https://www.ncbi.nlm.nih.gov/pubmed/26814430
http://dx.doi.org/10.18632/oncotarget.6974

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