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Paracrine effect of GTP cyclohydrolase and angiopoietin-1 interaction in stromal fibroblasts on tumor Tie2 activation and breast cancer growth

Cancer-associated fibroblasts (CAFs) play a key role in promoting tumor growth, acting through complex paracrine regulation. GTP cyclohydrolase (GTPCH) expression for tetrahydrobiopterin synthesis in tumor stroma is implicated in angiogenesis and tumor development. However, the clinical significance...

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Detalles Bibliográficos
Autores principales:	Chen, Liye, Zeng, Xin, Kleibeuker, Esther, Buffa, Francesca, Barberis, Alessandro, Leek, Russell D., Roxanis, Ioannis, Zhang, Wei, Worth, Andrew, Beech, John S., Harris, Adrian L., Cai, Shijie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891045/ https://www.ncbi.nlm.nih.gov/pubmed/26814432 http://dx.doi.org/10.18632/oncotarget.6981

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