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Increasing extracellular H(2)O(2) produces a bi-phasic response in intracellular H(2)O(2), with peroxiredoxin hyperoxidation only triggered once the cellular H(2)O(2)-buffering capacity is overwhelmed

Reactive oxygen species, such as H(2)O(2), can damage cells but also promote fundamental processes, including growth, differentiation and migration. The mechanisms allowing cells to differentially respond to toxic or signaling H(2)O(2) levels are poorly defined. Here we reveal that increasing extern...

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Detalles Bibliográficos
Autores principales: Tomalin, Lewis Elwood, Day, Alison Michelle, Underwood, Zoe Elizabeth, Smith, Graham Robert, Dalle Pezze, Piero, Rallis, Charalampos, Patel, Waseema, Dickinson, Bryan Craig, Bähler, Jürg, Brewer, Thomas Francis, Chang, Christopher Joh-Leung, Shanley, Daryl Pierson, Veal, Elizabeth Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891068/
https://www.ncbi.nlm.nih.gov/pubmed/26944189
http://dx.doi.org/10.1016/j.freeradbiomed.2016.02.035

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