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Increasing extracellular H(2)O(2) produces a bi-phasic response in intracellular H(2)O(2), with peroxiredoxin hyperoxidation only triggered once the cellular H(2)O(2)-buffering capacity is overwhelmed
Reactive oxygen species, such as H(2)O(2), can damage cells but also promote fundamental processes, including growth, differentiation and migration. The mechanisms allowing cells to differentially respond to toxic or signaling H(2)O(2) levels are poorly defined. Here we reveal that increasing extern...
Autores principales: | Tomalin, Lewis Elwood, Day, Alison Michelle, Underwood, Zoe Elizabeth, Smith, Graham Robert, Dalle Pezze, Piero, Rallis, Charalampos, Patel, Waseema, Dickinson, Bryan Craig, Bähler, Jürg, Brewer, Thomas Francis, Chang, Christopher Joh-Leung, Shanley, Daryl Pierson, Veal, Elizabeth Ann |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891068/ https://www.ncbi.nlm.nih.gov/pubmed/26944189 http://dx.doi.org/10.1016/j.freeradbiomed.2016.02.035 |
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